Department of Family Medicine, Daegu Medical Center, Daegu, South Korea.
Clin Endocrinol (Oxf). 2014 Jan;80(1):34-40. doi: 10.1111/cen.12246. Epub 2013 Jun 20.
Persistent elevation of urinary albumin excretion (UAE), even within normal range, is an independent predictor for cardiovascular disease. Accumulating research suggests that low levels of vitamin D and high levels of parathyroid hormone (PTH) also increase cardiovascular disease risk. This study is intended to investigate the relationship between PTH, vitamin D levels and UAE.
We examined 2897 adults aged 50 and above, participating in the second year of the fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2). Anthropometric and laboratory measurements were performed. Elevated UAE was defined as spot urinary albumin creatinine ratio equal or above 10.
The proportion of elevated UAE (21·8%, 23·2%, 23·2%, 31·8%; P for trend = 0·002) rose with increasing quartiles of PTH. The odds ratio for elevated UAE in the highest quartile of PTH was 72% higher than the lowest quartile group. There was no relationship between vitamin D and elevated UAE.
Elevated PTH levels are associated with elevated UAE in Korean adults aged 50 and above. Additional studies are needed to clarify this relationship.
尿白蛋白排泄率（UAE）持续升高，即使在正常范围内，也是心血管疾病的独立预测因素。越来越多的研究表明，维生素 D 水平低和甲状旁腺激素（PTH）水平高也会增加心血管疾病的风险。本研究旨在探讨 PTH、维生素 D 水平与 UAE 之间的关系。
我们检查了参加第五次韩国国家健康和营养检查调查（KNHANES V-2）第二年的 2897 名 50 岁及以上的成年人。进行了人体测量和实验室测量。尿白蛋白肌酐比等于或高于 10 定义为 UAE 升高。
随着 PTH 四分位值的升高，UAE 升高的比例（21.8%、23.2%、23.2%、31.8%；P 趋势=0.002）也随之升高。PTH 最高四分位数组 UAE 升高的比值比最低四分位数组高 72%。维生素 D 与 UAE 升高之间没有关系。
在 50 岁及以上的韩国成年人中，升高的 PTH 水平与 UAE 升高有关。需要进一步的研究来阐明这种关系。
