Rao Shilpa, Ravindra Niveditha, Sadashiva Nishanth, Indira Devi Bhagavatula, Santosh Vani
1 National Institute of Mental Health and Neurosciences, Bangalore, India.
Int J Surg Pathol. 2017 Oct;25(7):644-647. doi: 10.1177/1066896917710716. Epub 2017 May 29.
Ependymomas are glial neoplasms with rare cases exhibiting neuronal differentiation. We describe a case of spinal anaplastic ependymoma with ganglionic differentiation in a 28-year-old woman. The ganglionic component was labeled by synaptophysin, whereas the rest of the tumor showed features of an anaplastic ependymoma. Stem cell marker MELK was noted to stain both the neoplastic ependymal and ganglionic components, possibly suggesting a stem cell/progenitor origin for the tumor with subsequent divergent differentiation.
室管膜瘤是一种神经胶质肿瘤，少数病例可表现出神经元分化。我们描述了一例28岁女性的脊髓间变性室管膜瘤伴神经节分化。神经节成分被突触素标记，而肿瘤的其余部分表现出间变性室管膜瘤的特征。干细胞标志物MELK在肿瘤性室管膜和神经节成分中均有染色，这可能提示该肿瘤起源于干细胞/祖细胞，随后发生了分化。
