中国女性妊娠期糖尿病相关的基因变异及临床相关性：一项病例对照研究
Genetic variants and clinical relevance associated with gestational diabetes mellitus in Chinese women: a case-control study.
作者信息
Yan Jie, Su Rina, Ao Deng, Wang Yan, Wang Haijun, Yang Huixia
机构信息
a Department of Obstetrics and Gynecology , Peking University First Hospital , Beijing , China.
b Department of Child, Adolescent and Women's Health, School of Public Health , Peking University , Beijing , China.
出版信息
J Matern Fetal Neonatal Med. 2018 Aug;31(16):2115-2121. doi: 10.1080/14767058.2017.1336225. Epub 2017 Jun 14.
PURPOSE
Gestational diabetes mellitus (GDM) may share similar mechanisms with type 2 diabetes and obesity. In the current study, we aimed to verify twenty genes reported to be associated with type 2 diabetes and obesity in the Chinese GDM population.
METHODS
Pregnant women aged 20-49 years at 24-28 gestational weeks were recruited and 556 cases and 445 controls were enrolled in the study. The genotyping of single nucleotide polymorphisms (SNPs) was performed on peripheral blood samples.
RESULTS
We discovered that GDM was associated with rs945508 (OR = 1.368, 95% CI = 1.080-1.732, p = .009), rs10804591 (OR = 1.446, 95% CI = 1.192-1.754, p < .001), rs10245353 (OR = 1.204, 95% CI = 1.006-1.441, p = .043) and rs1552224 (OR = 1.451, 95% CI = 1.071-1.964, p = .016).
CONCLUSIONS
We found that four SNPs associated with type 2 diabetes and obesity may also increase the risk of developing GDM in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM.
目的
妊娠期糖尿病（GDM）可能与2型糖尿病和肥胖症具有相似的机制。在本研究中，我们旨在验证在中国GDM人群中报告的与2型糖尿病和肥胖症相关的20个基因。
方法
招募妊娠24 - 28周、年龄在20 - 49岁的孕妇，共纳入556例病例和445例对照。对外周血样本进行单核苷酸多态性（SNP）基因分型。
结果
我们发现GDM与rs945508（OR = 1.368，95%CI = 1.080 - 1.732，p = 0.009）、rs10804591（OR = 1.446，95%CI = 1.192 - 1.754，p < 0.001）、rs10245353（OR = 1.204，95%CI = 1.006 - 1.441，p = 0.043）和rs1552224（OR = 1.451，95%CI = 1.071 - 1.964，p = 0.016）相关。
结论
我们发现与2型糖尿病和肥胖症相关的四个SNP也可能增加中国人群发生GDM的风险。在这些SNP中，我们首次报告ARHGEF11中的rs945508、PLXND1中的rs10804591和NFE2L3中的rs10245353与GDM相关。
Zotero 插件