帕金森病临床鉴别诊断的进展
Advances in the Clinical Differential Diagnosis of Parkinson's Disease.
作者信息
Schreglmann Sebastian R, Bhatia Kailash P, Stamelou Maria
机构信息
Institute of Neurology, UCL, London, United Kingdom.
University of Athens Medical School, Hospital Attikon, Athens, Greece; HYGEIA Hospital, Athens, Greece; Philipps University, Marburg, Germany.
出版信息
Int Rev Neurobiol. 2017;132:79-127. doi: 10.1016/bs.irn.2017.01.007. Epub 2017 Mar 27.
The differential diagnosis of Parkinson's disease has widened considerably in recent years. This chapter aims to summarize the current knowledge on the clinical differential diagnoses of sporadic Parkinson's disease. As the number of monogenic familial Parkinson's disease variants and risk factors is growing, so is the number of appreciated etiologies of atypical parkinsonian and other pallidopyramidal syndromes. This work aims at summarizing the current knowledge on both motor and nonmotor neurological signs and symptoms that aid the clinical diagnosis of Parkinson's disease and its differential diagnoses.
近年来，帕金森病的鉴别诊断范围已大幅拓宽。本章旨在总结目前关于散发性帕金森病临床鉴别诊断的知识。随着单基因家族性帕金森病变异体和风险因素数量的增加，非典型帕金森综合征及其他苍白球-锥体束综合征的已知病因数量也在增加。这项工作旨在总结目前有关运动和非运动神经体征及症状的知识，这些体征和症状有助于帕金森病的临床诊断及其鉴别诊断。
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