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[非典型帕金森综合征]

[Atypical parkinsonian syndromes].

作者信息

Beal Charlotte, Durif Franck

机构信息

Service de neurologie, CHU de Clermont- Ferrand, Clermont- Ferrand, France.

出版信息

Rev Prat. 2021 Oct;71(8):875-883.

Abstract

ATYPICAL PARKINSONIAN SYNDROMES Idiopathic Parkinson's disease is the most common cause of parkinsonism, but in almost 40 % of cases, parkinsonism is due to other causes. The diagnosis of atypical parkinsonian syndromes remains difficult at the early stage. Parkinson's syndrome is associated with other symptoms called «red flags». These red flags need to be identified during the clinical examination. Unlike Parkinson's disease, dopaminergic treatment are slightly effective on motor symptoms. The prognosis is worst, with a faster progression. The life expectation is reduced compared to Parkinson's disease. Diagnosis certainty, given by anatomopathology, is not available during the patient's lifetime. Advances in functional imaging improve diagnosis accuracy. Clinical course answers diagnosis uncertainties in a few month or years. The follow up is multidisciplinary. No treatment is currently available.

摘要

非典型帕金森综合征 特发性帕金森病是帕金森综合征最常见的病因,但在近40%的病例中,帕金森综合征是由其他原因引起的。非典型帕金森综合征在早期诊断仍很困难。帕金森综合征与其他被称为“警示信号”的症状相关。这些警示信号需要在临床检查中识别出来。与帕金森病不同,多巴胺能治疗对运动症状的效果稍差。预后更差,进展更快。与帕金森病相比,预期寿命缩短。在患者有生之年无法通过解剖病理学获得确诊。功能成像的进展提高了诊断准确性。临床病程在几个月或几年内可解答诊断的不确定性。随访是多学科的。目前尚无有效治疗方法。

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