慢性脑室内注入神经分泌蛋白GL对雏鸡体重、食物和水摄入量的影响。
Effects of chronic intracerebroventricular infusion of neurosecretory protein GL on body mass and food and water intake in chicks.
作者信息
Shikano Kenshiro, Kato Masaki, Iwakoshi-Ukena Eiko, Furumitsu Megumi, Matsuura Daichi, Masuda Keiko, Tachibana Tetsuya, Bentley George E, Kriegsfeld Lance J, Ukena Kazuyoshi
机构信息
Section of Behavioral Sciences, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan.
Section of Behavioral Sciences, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan; Department of Integrative Biology, The Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA 94720-3140, USA.
出版信息
Gen Comp Endocrinol. 2018 Jan 15;256:37-42. doi: 10.1016/j.ygcen.2017.05.016. Epub 2017 May 26.
Recently, we discovered a novel cDNA encoding the precursor of a small secretory protein, neurosecretory protein GL (NPGL), in the chicken mediobasal hypothalamus. In this study, immunohistochemical analysis revealed that NPGL was produced in the infundibular and medial mammillary nuclei of the mediobasal hypothalamus, with immunoreactive fibers also detected in the hypothalamus and the median eminence. As it is known that these regions are involved in feeding behavior in chicks, we surveyed the effects of chronic intracerebroventricular infusion of NPGL on feeding behavior and body mass for a period of two weeks. NPGL stimulated food and water intake, with a concomitant increase in body mass. However, NPGL did not influence mRNA expression of several hypothalamic ingestion-related neuropeptides. Our data suggest that NPGL may be a novel neuronal regulator involved in growth processes in chicks.
最近，我们在鸡的中基底下丘脑发现了一种编码小分泌蛋白神经分泌蛋白GL（NPGL）前体的新cDNA。在本研究中，免疫组织化学分析显示，NPGL在下丘脑中间基底部的漏斗核和内侧乳头核中产生，在下丘脑和正中隆起中也检测到免疫反应性纤维。由于已知这些区域参与雏鸡的摄食行为，我们调查了连续两周脑室内注入NPGL对摄食行为和体重的影响。NPGL刺激食物和水的摄入，同时体重增加。然而，NPGL不影响几种下丘脑摄食相关神经肽的mRNA表达。我们的数据表明，NPGL可能是参与雏鸡生长过程的一种新型神经调节因子。
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