Viatte Sebastien, Barton Anne
Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust, Grafton Street, Manchester, M13 9WL, UK.
Semin Immunopathol. 2017 Jun;39(4):395-408. doi: 10.1007/s00281-017-0630-4. Epub 2017 May 29.
A decade after the first genome-wide association study in rheumatoid arthritis (RA), a plethora of genetic association studies have been published on RA and its clinical or serological subtypes. We review the major milestones in the study of the genetic architecture of RA susceptibility, severity, and response to treatment. We set the scientific context necessary for non-geneticists to understand the potential clinical applications of human genetics and its significance for a stratified approach to the management of RA in the future.
在类风湿关节炎（RA）首次进行全基因组关联研究的十年后，大量关于RA及其临床或血清学亚型的遗传关联研究已经发表。我们回顾了RA易感性、严重程度及治疗反应的遗传结构研究中的主要里程碑。我们设定了非遗传学家理解人类遗传学潜在临床应用及其对未来RA分层管理方法的意义所需的科学背景。
