Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Department of Health Screening and Promotion Center, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
J Gastroenterol Hepatol. 2018 Jan;33(1):180-186. doi: 10.1111/jgh.13833.
Smoking cessation is known to improve the course of Crohn's disease (CD). However, the factors associated with smoking cessation after CD diagnosis have not been well established.
Clinical characteristics and change in smoking status were evaluated in 445 current smokers at the time of CD diagnosis. Patients were classified into three subgroups based on their final smoking status and time of smoking cessation: non-quitters, quitters at diagnosis, and quitters during follow-up.
The overall smoking cessation rate was 55.7% (248 of 445 patients). The diagnosis of CD was the main reason for quitting (41.5%, 103 of 248 patients). Smoking cessation at the time of CD diagnosis was associated with intestinal resection within 3 months from CD diagnosis (odds ratio [OR] 2.355, 95% confidence interval [CI] 1.348-4.116, P = 0.003), light smoking (OR 2.041, 95% CI 1.157-3.602, P = 0.014), and initiation of smoking before 18 years of age (OR 0.570, 95% CI 0.327-0.994, P = 0.047). Light smoking (OR 1.762, 95% CI 1.019-3.144, P = 0.043) and initiation of smoking before 18 years (OR 0.588, 95% CI 0.381-0.908, P = 0.017) were also associated with overall smoking cessation.
Quitters after CD diagnosis, including quitters at diagnosis and quitters during follow-up, had features distinct from those of non-quitters. Given the motivation at CD diagnosis, a detailed history of smoking habits should be taken and all current smokers should be encouraged to quit smoking at the time of CD diagnosis.
戒烟被认为可以改善克罗恩病（CD）的病程。然而，与 CD 诊断后戒烟相关的因素尚未得到很好的确定。
在 CD 诊断时，对 445 名当前吸烟者的临床特征和吸烟状况变化进行了评估。根据最终吸烟状况和戒烟时间，将患者分为三组：未戒烟者、诊断时戒烟者和随访期间戒烟者。
总体戒烟率为 55.7%（248/445 例）。CD 的诊断是戒烟的主要原因（41.5%，248 例中有 103 例）。CD 诊断时的戒烟与 CD 诊断后 3 个月内进行肠道切除术（比值比[OR] 2.355，95%置信区间[CI] 1.348-4.116，P=0.003）、轻度吸烟（OR 2.041，95%CI 1.157-3.602，P=0.014）和 18 岁前开始吸烟（OR 0.570，95%CI 0.327-0.994，P=0.047）相关。轻度吸烟（OR 1.762，95%CI 1.019-3.144，P=0.043）和 18 岁前开始吸烟（OR 0.588，95%CI 0.381-0.908，P=0.017）也与总体戒烟相关。
CD 诊断后的戒烟者，包括诊断时戒烟者和随访期间戒烟者，与未戒烟者的特征不同。鉴于 CD 诊断时的动机，应详细了解吸烟习惯史，并鼓励所有当前吸烟者在 CD 诊断时戒烟。
