Department of Medicine, Division of Gastroenterology, Inflammatory Bowel Disease Clinic, University of Calgary, 3280 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.
Dig Dis Sci. 2012 Apr;57(4):1026-32. doi: 10.1007/s10620-012-2038-2. Epub 2012 Feb 7.
Patients with Crohn's disease (CD) who smoke have a more complicated disease course.
Our primary objective was to assess smoking related variables that were associated with smoking cessation versus continued smoking in patients with CD.
A multi-center study identified CD patients who were seen at the University of Chicago and University of Calgary IBD clinics. Patients were categorized into three subgroups: lifetime non-smokers, current smokers, or ex-smokers. Participants completed questionnaires assessing their cigarette smoking behavior. Current smokers were prospectively followed for 6 months to assess smoking status and attempts to quit. Logistic regression analysis was performed to identify factors associated with smoking cessation.
Three hundred patients were enrolled with 148 identifying themselves as lifetime non-smokers, 70 as current smokers, and 82 as ex-smokers. Patients who reported their first cigarette within 5 min of waking were more likely to be current smokers (OR = 21; 95% CI 3.94-107.3) as compared to patients who waited greater than 60 min. Current smokers were more likely to have one or more household members who smoked compared to ex-smokers (P < 0.05). Nearly half (49%) of the current smokers were in the precontemplation stage of change (i.e. no intention to quit smoking). At the 6-month follow-up, only 11% reported they quit smoking.
Patients who report a short time to first cigarette in the morning may have more difficulty in smoking cessation. Current smokers were more likely to have another smoker in the household compared to ex-smokers. Current smokers had low levels of motivation to quit smoking and consequently with no intervention, very few quit 6 months after the baseline assessment.
患有克罗恩病（CD）的吸烟者其疾病过程更为复杂。
我们的主要目的是评估与 CD 患者戒烟或继续吸烟相关的吸烟相关变量。
一项多中心研究确定了在芝加哥大学和卡尔加里大学 IBD 诊所就诊的 CD 患者。患者分为三组：终身不吸烟者、当前吸烟者或曾经吸烟者。参与者完成了评估其吸烟行为的问卷。当前吸烟者前瞻性随访 6 个月，以评估吸烟状况和戒烟尝试。进行逻辑回归分析以确定与戒烟相关的因素。
共纳入 300 名患者，其中 148 名患者为终身不吸烟者，70 名患者为当前吸烟者，82 名患者为曾经吸烟者。与等待超过 60 分钟的患者相比，报告醒来后 5 分钟内第一支烟的患者更有可能是当前吸烟者（OR=21；95%CI3.94-107.3）。与曾经吸烟者相比，当前吸烟者家中有一个或多个吸烟者的可能性更大（P<0.05）。近一半（49%）的当前吸烟者处于改变的前思考阶段（即无意戒烟）。在 6 个月的随访中，只有 11%的人报告他们已经戒烟。
早晨第一支烟的时间较短的患者可能更难以戒烟。与曾经吸烟者相比，当前吸烟者家中有吸烟者的可能性更大。当前吸烟者戒烟的动机水平较低，因此，如果没有干预措施，在基线评估后 6 个月内很少有人戒烟。
