Young T Kue, Nikitin Yuri P, Shubnikov Eugene V, Astakhova Tamara I, Moffatt Michael E K, O'Neil John D
Northern Health Research Unit, Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada R3E OW3.
Institute of Internal Medicine, Russian Academy of Medical Sciences, Siberian Branch, Novosibirsk, Russia.
Am J Hum Biol. 1995;7(2):223-236. doi: 10.1002/ajhb.1310070212.
The distribution of plasma lipids and their sociodemographic and metabolic correlates were investigated in two Arctic indigenous populations based on two health surveys conducted during 1990-1991 among adults in eight Inuit communities in the Keewatin region of the Northwest Territories, Canada (n = 387), and in four communities in the Chukotka region in the Russian Far North (n = 362). For comparison, data from the Canadian Heart Health Survey were used. The age-sex-specific mean total and low-density lipoprotein (LDL)-cholesterol levels among Inuit in northern Canada either do not differ significantly from the Canadian national population, or, in the case of younger Inuit women, are higher than in Canadians. This represents a temporal change from the results of earlier studies. Chukotka Natives tend to have the lowest total cholesterol (TC) and LDL values of the three populations. The two indigenous populations still enjoy considerably lower levels of triglycerides (TG) and higher levels of high density lipoprotein (HDL) cholesterol than observed in Canada, with the exception of younger Inuit women whose mean TG levels are not significantly different from those of Canadians. The proportion of individuals at risk for ischemic heart disease because of high TG (≥2.3 mmol/L) is 20% among Canadian men but only 2% and 0% among the Arctic Natives, and 11% among Canadian women compared to 6% and 3% in the Keewatin and Chukotka regions, respectively. Such sociodemographic factors as education and marital status do not have a substantial and consistent effect on plasma lipid levels. Women with higher education have lower HDL (in Keewatin) and higher TG (in Chukotka), significant only at the 0.10 level. Among Chukotka men those who reported a lineage without nonindigenous admixture have a higher HDL level (P = 0.048). No difference between the admixed and nonadmixed can be found in the Keewatin. Smoking status has no significant effect on any of the lipid fractions in either population. The two Arctic populations demonstrate an association of some plasma lipids with blood pressure and indices of obesity and central fat patterning commonly observed in other populations. However, plasma glucose does not increase in tandem with increasing levels of lipids, contrary to that observed in the general Canadian population. © 1995 Wiley-Liss, Inc.
基于1990 - 1991年期间在加拿大西北地区基韦廷地区八个因纽特社区的成年人中开展的两项健康调查（n = 387），以及在俄罗斯远北地区楚科奇地区四个社区的成年人中开展的两项健康调查（n = 362），对两个北极原住民群体的血浆脂质分布及其社会人口统计学和代谢相关性进行了研究。为作比较，使用了加拿大心脏健康调查的数据。加拿大北部因纽特人按年龄和性别划分的平均总胆固醇和低密度脂蛋白（LDL）胆固醇水平，与加拿大全国人口相比，要么没有显著差异，要么对于年轻的因纽特女性而言，高于加拿大人水平。这代表了与早期研究结果的时间变化。楚科奇原住民在这三个人口中总胆固醇（TC）和LDL值往往最低。这两个原住民群体的甘油三酯（TG）水平仍远低于加拿大，高密度脂蛋白（HDL）胆固醇水平则高于加拿大，但年轻因纽特女性除外，其平均TG水平与加拿大人无显著差异。因高TG（≥2.3 mmol/L）而有缺血性心脏病风险的个体比例，在加拿大男性中为20%，但在北极原住民中仅为2%和0%，在加拿大女性中为11%，而在基韦廷和楚科奇地区分别为6%和3%。教育和婚姻状况等社会人口统计学因素对血浆脂质水平没有实质性的一致影响。受过高等教育的女性HDL水平较低（在基韦廷）且TG水平较高（在楚科奇），仅在0.10水平有显著差异。在楚科奇男性中，那些报告没有非本地血统混合的人HDL水平较高（P = 0.048）。在基韦廷，混合血统和非混合血统之间未发现差异。吸烟状况对任何一个群体的任何脂质组分均无显著影响。这两个北极群体显示出一些血浆脂质与血压以及肥胖和中心性脂肪分布指数之间的关联，这在其他群体中也普遍存在。然而，与加拿大普通人群中观察到的情况相反，血浆葡萄糖水平并未随脂质水平升高而同步升高。© 1995威利 - 利斯公司。
