Connelly P W, MacLean D R, Horlick L, O'Connor B, Petrasovits A, Little J A
Department of Medicine, St. Michael's Hospital, Toronto, Ont.
CMAJ. 1992 Jun 1;146(11):1977-87.
To report population reference values for blood lipids, to determine the prevalence of lipid risk factors and to assess their association with other risk factors.
Population-based cross-sectional surveys. Survey participants were interviewed at home and provided a blood sample at a clinic. All blood lipid analyses were done in the Lipid Research Laboratory, University of Toronto. The laboratory is standardized in the National Heart, Lung Blood Institute-Centres for Disease Control Standardization Program.
Nine Canadian provinces, from 1986 to 1990.
A probability sample of 26,293 men and women aged 18 to 74 was selected from the health insurance registers for each province. Blood samples were obtained from 16,924 participants who had fasted 8 hours or more.
Concentration of total plasma cholesterol, triglycerides and high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol in blood samples from fasting participants.
Of the study population, 46% had total plasma cholesterol levels above 5.2 mmol/L, 15% had LDL-cholesterol levels above 4.1 mmol/L, 15% had triglyceride levels above 2.3 mmol/L and 8% had HDL-cholesterol levels below 0.9 mmol/L. Total plasma cholesterol, LDL-cholesterol and triglyceride levels rose with age in men to a maximum in the 45-54 age group; in women there was little change with age up to ages 45 to 54, at which time the level of each of these lipids increased appreciably. The age-standardized prevalence of obesity was positively associated with elevation of total plasma cholesterol.
The results suggest the need for a multifactorial approach in health promotion efforts to lower blood cholesterol levels and reduce other risk factors in the population. A considerable number of adults were found to be at risk at all ages in both sexes. In the short term, men aged 34 and older and women aged 45 and older might benefit most from prevention programs.
报告血脂的人群参考值，确定脂质危险因素的患病率，并评估其与其他危险因素的关联。
基于人群的横断面调查。对调查参与者进行家访，并在诊所采集血样。所有血脂分析均在多伦多大学脂质研究实验室进行。该实验室符合美国国立心肺血液研究所 - 疾病控制中心标准化项目的标准。
1986年至1990年期间加拿大的九个省份。
从每个省份的健康保险登记册中选取了26293名年龄在18至74岁之间的男性和女性作为概率样本。从16924名禁食8小时或更长时间的参与者中获取血样。
空腹参与者血样中总血浆胆固醇、甘油三酯、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）胆固醇的浓度。
在研究人群中，46%的人总血浆胆固醇水平高于5.2 mmol/L，15%的人LDL胆固醇水平高于4.1 mmol/L，15%的人甘油三酯水平高于2.3 mmol/L，8%的人HDL胆固醇水平低于0.9 mmol/L。男性的总血浆胆固醇、LDL胆固醇和甘油三酯水平随年龄增长而上升，在45 - 54岁年龄组达到最高；女性在45至54岁之前，这些脂质水平随年龄变化不大，此后每种脂质水平均显著升高。肥胖的年龄标准化患病率与总血浆胆固醇升高呈正相关。
结果表明，在健康促进工作中需要采取多因素方法来降低人群中的血液胆固醇水平并减少其他危险因素。发现相当数量的成年人在所有年龄段的男女中都有风险。短期内，34岁及以上的男性和45岁及以上的女性可能从预防计划中获益最大。
