Parker Gordon, Brotchie Heather
School of Psychiatry, University of New South Wales; and Black Dog Institute, Prince of Wales Hospital, Randwick, New South Wales, Australia.
J Nerv Ment Dis. 2017 Jun;205(6):487-490. doi: 10.1097/NMD.0000000000000593.
Depression is a common concomitant of pancreatic cancer, and, because it often occurs before the cancer is diagnosed, its occurrence is likely to be intrinsic to the condition rather than a reaction to such a diagnosis. Because pancreatic cancer is associated with a very high mortality, its early detection is a key task. We therefore review relevant literature to determine whether the depression is prototypically distinctive and whether its identification might lead to earlier diagnosis of pancreatic cancer. We report on the epidemiology and prognosis of pancreatic cancer and on the prevalence, description, and possible mechanisms involved for the occurrence of any associated depressive state, before reviewing the comparative utility of depression in relation to other risk factors in aiding diagnosis. Published studies fail to identify any distinct depressive prototypic phenotype to depression associated with pancreatic cancer. Although it is a relatively common concomitant of pancreatic cancer, the utility of depression as a marker of the condition is not suggested from a key study evaluating its contribution in relation to other symptoms and risk factors.
抑郁症是胰腺癌常见的伴随病症，而且由于它常常在癌症被诊断出来之前就出现，其发生可能是该病症本身所固有的，而非对这种诊断的反应。由于胰腺癌的死亡率非常高，早期检测是一项关键任务。因此，我们查阅相关文献，以确定抑郁症是否具有典型的独特性，以及对其识别是否可能导致胰腺癌的早期诊断。在回顾抑郁症相对于其他风险因素在辅助诊断方面的比较效用之前，我们报告了胰腺癌的流行病学和预后情况，以及任何相关抑郁状态的患病率、描述和可能涉及的机制。已发表的研究未能识别出与胰腺癌相关的抑郁症有任何独特的抑郁原型表型。尽管抑郁症是胰腺癌相对常见的伴随病症，但一项评估其与其他症状和风险因素相比作用的关键研究并未表明抑郁症可作为该病症的标志物。
