汉防己甲素对二氧化硅诱导的体外纤维化形成的抑制作用研究。
Studies on the inhibitory effect of tetrandrine on silica-induced fibrogenesis in vitro.
作者信息
Li Y R, Cai G P, Liu L F, Chen N M, Li C L
机构信息
Section of Pneumoconiosis, Chinese Academy of Preventive Medicine, Beijing.
出版信息
Biomed Environ Sci. 1988 Aug;1(2):125-9.
Two cell culture systems composed of rat peritoneal macrophages and 2BS fibroblasts were used to study the inhibitory action of tetrandrine on collagen and glycosaminoglycan synthesis. The activation of silica-treated macrophage supernatants stimulated collagen synthesis by 2BS fibroblast cells. Tetrandrine had an inhibitory effect on the biosynthesis of collagen and glycosaminoglycans. The increase in the content of hydroxyproline, representing collagen, was verified by comparing it with that of DNA.
采用由大鼠腹腔巨噬细胞和2BS成纤维细胞组成的两种细胞培养系统，研究粉防己碱对胶原蛋白和糖胺聚糖合成的抑制作用。经二氧化硅处理的巨噬细胞上清液的激活可刺激2BS成纤维细胞合成胶原蛋白。粉防己碱对胶原蛋白和糖胺聚糖的生物合成有抑制作用。通过与DNA含量比较，证实了代表胶原蛋白的羟脯氨酸含量的增加。
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