地塞米松植入物对糖尿病性黄斑水肿患者黄斑形态和视觉功能的早期影响
Early Effects of Dexamethasone Implant on Macular Morphology and Visual Function in Patients with Diabetic Macular Edema.
作者信息
Veritti Daniele, Sarao Valentina, Galiazzo Francesco, Lanzetta Paolo
机构信息
Department of Medicine-Ophthalmology, University of Udine, Udine, Italy.
出版信息
Ophthalmologica. 2017;238(1-2):100-105. doi: 10.1159/000475889. Epub 2017 May 31.
PURPOSE
To evaluate the early effects of dexamethasone implant in patients with diabetic macular edema (DME).
METHODS
Eyes with DME were prospectively included in the study. Best-corrected visual acuity (BCVA) measurement, complete ophthalmic evaluation, and spectral-domain optical coherence tomography were performed at baseline and 1, 2, 3, 7, 14, 21, 28, 60, and 90 days after treatment.
RESULTS
Twenty-three eyes of 20 patients were included in the study. Mean central retinal thickness (CRT) decreased rapidly after treatment (p < 0.0001, repeated measures ANOVA) from 511 μm at baseline to 469 μm after 1 day (p < 0.05), and 275 μm (p < 0.01) at the end of the follow-up. BCVA gain (p < 0.0001, repeated measures ANOVA) was on average +2 ETDRS letters at day 1 (not significant), +9 letters from day 28 to day 90 (p < 0.01).
CONCLUSION
Intravitreal dexamethasone implant showed an early and fast effect in reducing CRT and improving BCVA in DME patients.
目的
评估地塞米松植入物对糖尿病性黄斑水肿（DME）患者的早期疗效。
方法
前瞻性纳入患有DME的眼睛进行研究。在治疗前及治疗后1、2、3、7、14、21、28、60和90天进行最佳矫正视力（BCVA）测量、全面眼科评估和频域光学相干断层扫描。
结果
20例患者的23只眼睛纳入研究。治疗后平均中央视网膜厚度（CRT）迅速下降（p<0.0001，重复测量方差分析），从基线时的511μm降至1天后的469μm（p<0.05），随访结束时降至275μm（p<0.01）。BCVA提高（p<0.0001，重复测量方差分析），第1天平均提高+2个ETDRS字母（无统计学意义），从第28天到第90天提高+9个字母（p<0.01）。
结论
玻璃体内注射地塞米松植入物在降低DME患者的CRT和改善BCVA方面显示出早期快速疗效。
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