糖尿病性黄斑水肿患者房水中葡萄糖调节蛋白 78 的研究。
Glucose-Regulated Protein 78 in the Aqueous Humor of Patients with Diabetic Macular Edema.
机构信息
Department of Ophthalmology, St. Vincent's Hospital, College of Medicine, Catholic University of Korea, Republic of Korea.
出版信息
J Diabetes Res. 2020 Feb 23;2020:1640162. doi: 10.1155/2020/1640162. eCollection 2020.
PURPOSE
We identified the associations between levels of aqueous glucose-regulated protein 78 (GRP78) and systemic or ocular factors in patients with center-involving diabetic macular edema (CIDME).
METHODS
We measured the aqueous concentrations of GRP78, interleukin- (IL-) 1, IL-2, IL-8, IL-10, and IL-17, placental growth factor, and vascular endothelial growth factor (VEGF). We explored the associations between aqueous GRP78 levels and those of other aqueous factors, optical coherence tomography (OCT) findings, and systemic parameters in CIDME patients.
RESULTS
In multivariate regression analysis, aqueous GRP78 levels were associated with aqueous VEGF levels ( = 0.007), length of EZ disruption ( = 0.007), length of EZ disruption ( = 0.007), length of EZ disruption ( = 0.007), length of EZ disruption (.
CONCLUSIONS
Aqueous GRP78 levels correlated with VEGF levels in the aqueous humor and EZ disruption on OCT. However, GRP78 levels were not associated with those of inflammatory biomarkers in the aqueous humor or OCT findings. Additionally, GRP78 could not serve as a biomarker to predict short-term prognosis of anti-VEGF agent.
目的
我们确定了在伴有中心性糖尿病黄斑水肿（CIDME）的患者中，房水中葡萄糖调节蛋白 78（GRP78）水平与全身或眼部因素之间的相关性。
方法
我们测量了房水中 GRP78、白细胞介素（IL）-1、IL-2、IL-8、IL-10、IL-17、胎盘生长因子和血管内皮生长因子（VEGF）的浓度。我们探讨了房水中 GRP78 水平与其他房水因子、光学相干断层扫描（OCT）结果以及 CIDME 患者全身参数之间的关系。
结果
在多变量回归分析中，房水中的 GRP78 水平与房水中的 VEGF 水平相关（ = 0.007），与外节（EZ）破坏的长度相关（ = 0.007），与内节（IS）破坏的长度相关（ = 0.007），与内节（IS）破坏的长度相关（ = 0.007）。
结论
房水中的 GRP78 水平与房水中的 VEGF 水平以及 OCT 上的 EZ 破坏相关。然而，GRP78 水平与房水中的炎症生物标志物或 OCT 结果无关。此外，GRP78 不能作为预测抗 VEGF 药物短期预后的生物标志物。
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