Otsuka Ryota, Akutsu Yasunori, Sakata Haruhito, Hanari Naoyuki, Murakami Kentaro, Kano Masayuki, Takahashi Masahiko, Matsumoto Yasunori, Sekino Nobufumi, Yokoyama Masaya, Iida Keiko, Matsubara Hisahiro
Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Oncology. 2017;93(3):197-203. doi: 10.1159/000476068. Epub 2017 May 31.
ZNF750, an epidermal differentiation regulator, has been suggested to act as a tumor suppressor of esophageal squamous cell carcinoma (ESCC). Although a correlation between the epidermal differentiation gene and resistance to chemoradiotherapy (CRT) has been posited, no data regarding the ZNF750 status in ESCC have been reported. The aim of the present study was to evaluate the relationship between ZNF750 expression and response to CRT in ESCC.
Eighty-seven patients who had been pathologically diagnosed with ESCC were evaluated in the present study. All patients underwent neoadjuvant CRT, followed by curative esophagectomy. The expression of ZNF750 in pretreatment biopsy samples was immunohistochemically investigated and compared to the histopathological effectiveness of CRT in surgical specimens.
High expression of ZNF750 was closely correlated with good sensitivity to CRT (p = 0.016). A univariate analysis showed that high/intermediate expression of ZNF750 was a significant predictive factor for good sensitivity to CRT (p = 0.006). High/intermediate expression of ZNF750 (30% or more) remained an independent predictive factor for sensitivity to CRT in a multivariate analysis (p = 0.033).
ZNF750 expression predicts sensitivity to CRT and can be a biomarker that reliably predicts the response of ESCC to CRT.
ZNF750作为一种表皮分化调节因子，被认为是食管鳞状细胞癌（ESCC）的肿瘤抑制因子。尽管表皮分化基因与放化疗（CRT）耐药性之间的相关性已得到推测，但尚无关于ESCC中ZNF750状态的数据报道。本研究的目的是评估ZNF750表达与ESCC对CRT反应之间的关系。
本研究评估了87例经病理诊断为ESCC的患者。所有患者均接受新辅助CRT，随后进行根治性食管切除术。采用免疫组织化学方法研究预处理活检样本中ZNF750的表达，并与手术标本中CRT的组织病理学疗效进行比较。
ZNF750的高表达与对CRT的良好敏感性密切相关（p = 0.016）。单因素分析显示，ZNF750的高/中度表达是对CRT具有良好敏感性的显著预测因素（p = 0.006）。在多因素分析中，ZNF750的高/中度表达（30%或更高）仍然是对CRT敏感性的独立预测因素（p = 0.033）。
ZNF750表达可预测对CRT的敏感性，并且可以作为可靠预测ESCC对CRT反应的生物标志物。
