• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
ZNF750 Expression Is a Potential Prognostic Biomarker in Esophageal Squamous Cell Carcinoma.ZNF750表达是食管鳞状细胞癌潜在的预后生物标志物。
Oncology. 2018;94(3):142-148. doi: 10.1159/000484932. Epub 2017 Dec 8.
2
ZNF750 Expression as a Novel Candidate Biomarker of Chemoradiosensitivity in Esophageal Squamous Cell Carcinoma.ZNF750表达作为食管鳞状细胞癌放化疗敏感性的新型候选生物标志物
Oncology. 2017;93(3):197-203. doi: 10.1159/000476068. Epub 2017 May 31.
3
[Function and mechanism of zinc finger protein ZNF50 in inhibiting the growth of esophageal squamous cell carcinoma cells].锌指蛋白ZNF50抑制食管鳞状细胞癌细胞生长的作用及机制
Zhonghua Zhong Liu Za Zhi. 2017 Jan 23;39(1):7-12. doi: 10.3760/cma.j.issn.0253-3766.2017.01.002.
4
Downregulation of SIRT4 Expression Is Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma.SIRT4表达下调与食管鳞状细胞癌的不良预后相关。
Oncology. 2016;90(6):347-55. doi: 10.1159/000445323. Epub 2016 Apr 16.
5
Upregulation of PDK1 associates with poor prognosis in esophageal squamous cell carcinoma with facilitating tumorigenicity in vitro.PDK1的上调与食管鳞状细胞癌的不良预后相关，且在体外促进肿瘤发生。
Med Oncol. 2014 Dec;31(12):337. doi: 10.1007/s12032-014-0337-5. Epub 2014 Nov 22.
6
High expression of TACC3 in esophageal squamous cell carcinoma correlates with poor prognosis.TACC3在食管鳞状细胞癌中的高表达与预后不良相关。
Oncotarget. 2015 Mar 30;6(9):6850-61. doi: 10.18632/oncotarget.3190.
7
PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma.PFN2是一种预后不良的新型标志物，是参与食管鳞状细胞癌的潜在治疗靶点。
J Transl Med. 2016 May 17;14(1):137. doi: 10.1186/s12967-016-0884-y.
8
Overexpression of CD9 correlates with tumor stage and lymph node metastasis in esophageal squamous cell carcinoma.CD9的过表达与食管鳞状细胞癌的肿瘤分期及淋巴结转移相关。
Int J Clin Exp Pathol. 2015 Mar 1;8(3):3054-61. eCollection 2015.
9
Musashi1, a potential prognostic marker in esophageal squamous cell carcinoma.Musashi1，一种食管鳞状细胞癌潜在的预后标志物。
Oncol Rep. 2017 Sep;38(3):1724-1732. doi: 10.3892/or.2017.5809. Epub 2017 Jul 12.
10
[Expression and significance of FoxM1 in esophageal squamous cell carcinoma cells in vitro and in vivo].[FoxM1在食管鳞状细胞癌细胞中的体内外表达及意义]
Zhonghua Zhong Liu Za Zhi. 2016 Mar 23;38(3):179-84. doi: 10.3760/cma.j.issn.0253-3766.2016.03.004.

引用本文的文献

1
TRIM-endous functional network of tripartite motif 29 (TRIM29) in cancer progression and beyond.肿瘤进展及其他方面中具有巨大功能的三重基序29（TRIM29）网络。
Cancer Metastasis Rev. 2024 Dec 7;44(1):16. doi: 10.1007/s10555-024-10226-2.
2
Identification of POU4F1 as a novel prognostic biomarker and therapeutic target in esophageal squamous cell carcinoma.鉴定POU4F1作为食管鳞状细胞癌一种新的预后生物标志物和治疗靶点。
Cancer Cell Int. 2024 Aug 9;24(1):280. doi: 10.1186/s12935-024-03471-6.
3
Comprehensive pan-cancer analysis of ZNF337 as a potential diagnostic, immunological, and prognostic biomarker.全面泛癌分析 ZNF337 作为一种潜在的诊断、免疫和预后生物标志物。
BMC Cancer. 2024 Aug 9;24(1):987. doi: 10.1186/s12885-024-12703-x.
4
TRIM29 hypermethylation drives esophageal cancer progression via suppression of ZNF750.TRIM29高甲基化通过抑制ZNF750促进食管癌进展。
Cell Death Discov. 2023 Jun 26;9(1):191. doi: 10.1038/s41420-023-01491-1.
5
ZNF750: A Novel Prognostic Biomarker in Metastatic Prostate Cancer.ZNF750：转移性前列腺癌的新型预后生物标志物。
Int J Mol Sci. 2023 Mar 30;24(7):6519. doi: 10.3390/ijms24076519.
6
Zinc Finger Proteins: Functions and Mechanisms in Colon Cancer.锌指蛋白：在结肠癌中的功能与机制
Cancers (Basel). 2022 Oct 26;14(21):5242. doi: 10.3390/cancers14215242.
7
Novel ratio-metric features enable the identification of new driver genes across cancer types.新型比率度量特征可识别跨癌症类型的新驱动基因。
Sci Rep. 2022 Jan 7;12(1):5. doi: 10.1038/s41598-021-04015-y.
8
Zinc-finger protein 750 mitigates malignant biological behavior of oral CSC-like cells enriched from parental CAL-27 cells.锌指蛋白750减轻了从亲代CAL-27细胞富集的口腔癌干细胞样细胞的恶性生物学行为。
Oncol Lett. 2022 Jan;23(1):28. doi: 10.3892/ol.2021.13146. Epub 2021 Nov 19.
9
Developing ZNF Gene Signatures Predicting Radiosensitivity of Patients with Breast Cancer.开发预测乳腺癌患者放射敏感性的锌指蛋白（ZNF）基因特征
J Oncol. 2021 Aug 31;2021:9255494. doi: 10.1155/2021/9255494. eCollection 2021.
10
PAX6 upstream antisense RNA (PAUPAR) inhibits colorectal cancer progression through modulation of the microRNA (miR)-17-5p / zinc finger protein 750 (ZNF750) axis.PAX6上游反义RNA（PAUPAR）通过调节微小RNA（miR）-17-5p/锌指蛋白750（ZNF750）轴抑制结直肠癌进展。
Bioengineered. 2021 Dec;12(1):3886-3899. doi: 10.1080/21655979.2021.1940071.

本文引用的文献

1
ZNF750 Expression as a Novel Candidate Biomarker of Chemoradiosensitivity in Esophageal Squamous Cell Carcinoma.ZNF750表达作为食管鳞状细胞癌放化疗敏感性的新型候选生物标志物
Oncology. 2017;93(3):197-203. doi: 10.1159/000476068. Epub 2017 May 31.
2
ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma.ZNF750是鳞状细胞癌中一种谱系特异性肿瘤抑制因子。
Oncogene. 2017 Apr 20;36(16):2243-2254. doi: 10.1038/onc.2016.377. Epub 2016 Nov 7.
3
MicroRNA-10b regulates epithelial-mesenchymal transition by modulating KLF4/Notch1/E-cadherin in cisplatin-resistant nasopharyngeal carcinoma cells.微小RNA-10b通过调控顺铂耐药鼻咽癌细胞中的KLF4/Notch1/上皮钙黏蛋白来调节上皮-间质转化。
Am J Cancer Res. 2016 Jan 15;6(2):141-56. eCollection 2016.
4
Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population.日本人群食管鳞癌的基因组特征。
Gastroenterology. 2016 May;150(5):1171-1182. doi: 10.1053/j.gastro.2016.01.035. Epub 2016 Feb 10.
5
CRCT1 regulated by microRNA-520 g inhibits proliferation and induces apoptosis in esophageal squamous cell cancer.受微小RNA-520g调控的CRCT1抑制食管鳞状细胞癌的增殖并诱导其凋亡。
Tumour Biol. 2016 Jun;37(6):8271-9. doi: 10.1007/s13277-015-4730-2. Epub 2015 Dec 30.
6
Krüppel-like Factor 4 Promotes Esophageal Squamous Cell Carcinoma Differentiation by Up-regulating Keratin 13 Expression.Krüppel样因子4通过上调角蛋白13的表达促进食管鳞状细胞癌的分化。
J Biol Chem. 2015 May 22;290(21):13567-77. doi: 10.1074/jbc.M114.629717. Epub 2015 Apr 7.
7
Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma.基因组分析揭示了食管鳞状细胞癌中的突变特征和频繁改变的基因。
Am J Hum Genet. 2015 Apr 2;96(4):597-611. doi: 10.1016/j.ajhg.2015.02.017.
8
Association of Kruppel-like factor 4 expression with the prognosis of esophageal squamous cell carcinoma patients.Kruppel样因子4表达与食管鳞状细胞癌患者预后的关系
Int J Clin Exp Pathol. 2014 Sep 15;7(10):6679-85. eCollection 2014.
9
ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes.ZNF750 与 KLF4 和 RCOR1、KDM1A 以及 CTBP1/2 染色质调控因子相互作用，抑制表皮祖细胞基因并诱导分化基因。
Genes Dev. 2014 Sep 15;28(18):2013-26. doi: 10.1101/gad.246579.114.
10
Epidermal differentiation complex (locus 1q21) gene expression in head and neck cancer and normal mucosa.头颈部癌及正常黏膜中表皮分化复合体（1q21位点）基因的表达
Folia Histochem Cytobiol. 2014;52(2):79-89. doi: 10.5603/FHC.2014.0018.

ZNF750表达是食管鳞状细胞癌潜在的预后生物标志物。

ZNF750 Expression Is a Potential Prognostic Biomarker in Esophageal Squamous Cell Carcinoma.

作者信息

Otsuka Ryota, Akutsu Yasunori, Sakata Haruhito, Hanari Naoyuki, Murakami Kentaro, Kano Masayuki, Toyozumi Takeshi, Takahashi Masahiko, Matsumoto Yasunori, Sekino Nobufumi, Yokoyama Masaya, Okada Koichiro, Shiraishi Tadashi, Komatsu Aki, Iida Keiko, Matsubara Hisahiro

机构信息

Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

出版信息

Oncology. 2018;94(3):142-148. doi: 10.1159/000484932. Epub 2017 Dec 8.

DOI:10.1159/000484932
PMID:29216641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5969074/
Abstract

OBJECTIVE

ZNF750, a transcriptional regulator of epidermal differentiation, has been identified as a tumor suppressor in esophageal squamous cell carcinoma (ESCC). The aim of the present study was to investigate the clinical and prognostic significance of ZNF750 expression and to evaluate the effect of ZNF750 knockdown on cell proliferation, migration, and invasion in ESCC.

METHODS

A total of 124 patients with ESCC who underwent curative esophagectomy were evaluated in this study. The expression of ZNF750 in surgical specimens was immunohistochemically assessed and used in the analysis of clinicopathological features and overall survival (OS). The molecular role of ZNF750 was investigated by ZNF750 knockdown using small interfering RNA (siRNA) in ESCC cell lines.

RESULTS

Low ZNF750 expression had a significant correlation with positive lymph node metastasis (p = 0.028). Furthermore, there was a significant relationship between low expression of ZNF750 in ESCC and a poor OS, and a multivariate analysis showed that low ZNF750 expression was an independent prognostic factor (p = 0.020). The cell growth, migration, and invasion were significantly increased by downregulation of ZNF750.

CONCLUSIONS

The low expression of ZNF750 was significantly associated with a poor prognosis, and ZNF750 expression may, therefore, be a reliable prognostic biomarker in ESCC.

摘要

目的

ZNF750是一种表皮分化的转录调节因子，已被确定为食管鳞状细胞癌（ESCC）的肿瘤抑制因子。本研究的目的是探讨ZNF750表达的临床和预后意义，并评估ZNF750基因敲低对ESCC细胞增殖、迁移和侵袭的影响。

方法

本研究共评估了124例行根治性食管切除术的ESCC患者。通过免疫组织化学方法评估手术标本中ZNF750的表达，并用于分析临床病理特征和总生存期（OS）。在ESCC细胞系中使用小干扰RNA（siRNA）敲低ZNF750来研究其分子作用。

结果

ZNF750低表达与阳性淋巴结转移显著相关（p = 0.028）。此外，ESCC中ZNF750低表达与不良OS之间存在显著关系，多因素分析显示ZNF750低表达是独立的预后因素（p = 0.020）。ZNF750下调显著增加了细胞生长、迁移和侵袭。

结论

ZNF750低表达与不良预后显著相关，因此ZNF750表达可能是ESCC中一种可靠的预后生物标志物。