Ren J, Yang H, Lyu D, Zou J, Zheng Y T, Wang H Y
Department of Otorhinolarnygology Head and Neck Surgery, West China Hospital, Si Chuan University, Chengdu 610041, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 May 7;52(5):381-384. doi: 10.3760/cma.j.issn.1673-0860.2017.05.012.
To investigate the clinical and pathological features and prognosis of white lesion of vocal cord. One hundred and fifty-four cases of white lesion of vocal cord from January 2009 to February 2016 were retrospectively analysed. All the patients had undergone the resection of white lesion of vocal cord resection through retaining laryngoscope under general anesthesia with the specimens pathologically examined. There were 148 males and 6 females in this study. The ages ranged from 36 to 83 years, and the median age was 54.5.There were 103(66.88%) long-term smokers, and 64(41.56%) long-term drinkers. Postoperative pathology showed that chronic mucosal inflammation in 19 cases (12.34%), squamous epithelial hyperplasia in 56 cases(36.36%), mild dysplasia in 25 cases(16.23%), moderate dysplasia in 34 cases(22.08%), severe dysplasia in 12 cases(7.79%), carcinoma in 6 cases(3.90%), and invasive carcinoma in 2 cases(1.30%). The recurrence rate and canceration rate of chronic mucosal inflammation were 0. The recurrence rate of squamous epithelial hyperplasia was 10.71%, the canceration rate was 0.The recurrence rate of mild dysplasia was 8.00%, the canceration rate was 0. The recurrence rate of moderate dysplasia was 20.59%, the canceration rate was 8.82%. The recurrence rate of severe dysplasia was 25.00%, the canceration rate was 16.67%. White lesion of vocal cord is a predominantly male disease. Long-term smokering and drinking are one of common causes. The final diagnosis of white lesion of vocal cord relies on the pathology. Closed observation is necessary for theses dysplasia cases. The majority of which are benign, the operation effect is good.
探讨声带白色病变的临床病理特征及预后。回顾性分析2009年1月至2016年2月间154例声带白色病变患者。所有患者均在全身麻醉下经支撑喉镜行声带白色病变切除术，标本送病理检查。本研究中男性148例，女性6例。年龄范围为36至83岁，中位年龄为54.5岁。长期吸烟者103例（66.88%），长期饮酒者64例（41.56%）。术后病理显示，慢性黏膜炎症19例（12.34%），鳞状上皮增生56例（36.36%），轻度异型增生25例（16.23%），中度异型增生34例（22.08%），重度异型增生12例（7.79%），癌6例（3.90%），浸润癌2例（1.30%）。慢性黏膜炎症的复发率和癌变率均为0。鳞状上皮增生的复发率为10.71%，癌变率为0。轻度异型增生的复发率为8.00%，癌变率为0。中度异型增生的复发率为20.59%，癌变率为8.82%。重度异型增生的复发率为25.00%，癌变率为16.67%。声带白色病变以男性为主。长期吸烟和饮酒是常见病因之一。声带白色病变的最终诊断依赖于病理检查。对于这些异型增生病例，密切观察是必要的。其中大多数为良性，手术效果良好。
