Tarantino Vincenza, Vindigni Vincenzo, Bassetto Franco, Pavan Chiara, Vallesi Antonino
Department of Neuroscience, University of Padua, via Giustiniani 5, 35128, Padua, Italy.
Department of Neuroscience, University of Padua, via Giustiniani 5, 35128, Padua, Italy.
Biol Psychol. 2017 Jul;127:198-208. doi: 10.1016/j.biopsycho.2017.05.012. Epub 2017 May 27.
Impaired cognitive control functions have been documented in obesity. It remains unclear whether these functions normalize after weight reduction. We compared ex-obese individuals, who successfully underwent substantial weight loss after bariatric surgery, to normal-weight participants on measures of resistance to interference, cognitive flexibility and response inhibition, obtained from the completion of two Stroop tasks, a Switching task and a Go/NoGo task, respectively. To elucidate the underlying brain mechanisms, event-related potentials (ERPs) in the latter two tasks were examined. As compared to controls, patients were more susceptible to the predominant but task-irrelevant stimulus dimension (i.e., they showed a larger verbal Stroop effect), and were slower in responding on trials requiring a task-set change rather than a task-set repetition (i.e., they showed a larger switch cost). The ERP correlates revealed altered anticipatory control mechanisms (switch positivity) and an exaggerated conflict monitoring response (N2). The results suggest that cognitive control is critical even in ex-obese individuals and should be monitored to promote weight loss maintenance.
肥胖人群中已发现存在认知控制功能受损的情况。体重减轻后这些功能是否恢复正常仍不清楚。我们将接受减肥手术后成功大幅减重的肥胖症康复者与体重正常的参与者进行了比较，分别通过两项Stroop任务、一项切换任务和一项Go/NoGo任务的完成情况，对他们的抗干扰能力、认知灵活性和反应抑制能力进行了测量。为了阐明潜在的大脑机制，我们检查了后两项任务中的事件相关电位（ERP）。与对照组相比，患者更容易受到占主导地位但与任务无关的刺激维度的影响（即他们表现出更大的言语Stroop效应），并且在需要改变任务集而非重复任务集的试验中反应更慢（即他们表现出更大的切换成本）。ERP相关性显示预期控制机制（切换正波）发生改变，冲突监测反应（N2）过度增强。结果表明，即使在肥胖症康复者中，认知控制也很关键，应予以监测以促进体重减轻后的维持。
