二甲双胍辅助治疗不能提高一线抗结核方案对小鼠的杀菌活性。
Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice.
作者信息
Dutta Noton K, Pinn Michael L, Karakousis Petros C
机构信息
Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
出版信息
Antimicrob Agents Chemother. 2017 Jul 25;61(8). doi: 10.1128/AAC.00652-17. Print 2017 Aug.
Abstract
Preliminary preclinical and observational studies suggest the potential utility of metformin as an adjunctive, host-directed agent for treatment of tuberculosis (TB). In this study, we sought to investigate the bactericidal and sterilizing activities of human-like exposures of metformin when given in combination with the first-line regimen against chronic tuberculosis in BALB/c mice. Mice receiving metformin adjunctive therapy had similar lung bacillary burdens with control mice during treatment, and the proportion of mice with microbiological relapse was similar between the two groups.
摘要
临床前初步研究和观察性研究表明，二甲双胍作为一种辅助性宿主导向药物治疗结核病（TB）具有潜在效用。在本研究中，我们试图研究在BALB/c小鼠中，将与一线治疗方案联合使用的类人剂量二甲双胍用于治疗慢性结核病时的杀菌和灭菌活性。接受二甲双胍辅助治疗的小鼠在治疗期间的肺部杆菌负荷与对照小鼠相似，两组之间微生物学复发小鼠的比例也相似。
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