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富克斯综合征:1例病例的医学治疗及文献综述

Fuchs Syndrome: Medical Treatment of 1 Case and Literature Review.

作者信息

Gossart Rémy, Malthiery Eve, Aguilar Fanny, Torres Jacques-Henri, Fauroux Marie-Alix

机构信息

Department of Odontology, University Hospital of Montpellier, Montpellier, France.

出版信息

Case Rep Dermatol. 2017 Apr 18;9(1):114-120. doi: 10.1159/000468978. eCollection 2017 Jan-Apr.

DOI:10.1159/000468978
PMID:28559809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5437436/
Abstract

Fuchs syndrome is a particular type of erythema multiforme major; the lesions are only found on the mucosae and specifically affect oral, ocular, and genital mucosae. The cause is not always immediately apparent, which is why this pathology requires a rigorous, detailed clinical examination to eliminate a differential diagnosis. The severity of the symptoms, particularly of oral and ocular symptoms, requires immediate treatment. The treatment of this pathology requires a multiple-drug regime. Through a clinical case study, the objective of this work is to help guide practitioners when diagnosing and treating this pathology as no current consensus exists on these 2 subjects. The authors present the case of a 29-year-old patient who was suffering from a recurring outbreak of Fuchs syndrome, suspected of having been triggered by . After completing the treatment program based on colchicine and prednisolone, the patient was relieved from pain and has not suffered from any further periodic eruptions of erythema multiforme.

摘要

富克斯综合征是一种特殊类型的重症多形红斑;病变仅见于黏膜,尤其累及口腔、眼部和生殖器黏膜。病因并非总是立即可见,这就是为什么这种病症需要进行严格、详细的临床检查以排除鉴别诊断。症状的严重程度,尤其是口腔和眼部症状,需要立即治疗。这种病症的治疗需要多种药物联合使用。通过一个临床病例研究,这项工作的目的是在诊断和治疗这种病症时帮助指导从业者,因为目前在这两个问题上尚无共识。作者介绍了一名29岁患者的病例,该患者患有复发性富克斯综合征,怀疑是由……引发的。在完成基于秋水仙碱和泼尼松龙的治疗方案后,患者疼痛缓解,且未再出现多形红斑的周期性发作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5437436/9f0435c2632e/cde-0009-0114-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5437436/685fceee2785/cde-0009-0114-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5437436/e9fd42095a6f/cde-0009-0114-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5437436/80f78277fe69/cde-0009-0114-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5437436/83d7e8f1f209/cde-0009-0114-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5437436/9f0435c2632e/cde-0009-0114-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5437436/685fceee2785/cde-0009-0114-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5437436/e9fd42095a6f/cde-0009-0114-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5437436/80f78277fe69/cde-0009-0114-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5437436/83d7e8f1f209/cde-0009-0114-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/5437436/9f0435c2632e/cde-0009-0114-g05.jpg

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本文引用的文献

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Long-term valacyclovir treatment and immune modulation for Herpes-associated erythema multiforme.长期使用伐昔洛韦治疗及免疫调节用于疱疹相关性多形红斑。
Cent Eur J Immunol. 2015;40(3):387-90. doi: 10.5114/ceji.2015.54604. Epub 2015 Oct 15.
2
Mycoplasma pneumoniae-induced rash and mucositis as a syndrome distinct from Stevens-Johnson syndrome and erythema multiforme: a systematic review.肺炎支原体感染相关性皮疹和黏膜炎综合征与史蒂文斯-约翰逊综合征和多形红斑的区别:系统评价。
J Am Acad Dermatol. 2015 Feb;72(2):239-45. doi: 10.1016/j.jaad.2014.06.026.
3
Stevens-Johnson syndrome without skin lesions (Fuchs syndrome): a literature review of adult cases with Mycoplasma cause.
Clin Rev Allergy Immunol. 2018 Feb;54(1):177-184. doi: 10.1007/s12016-017-8667-7.
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Current Perspectives on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的最新观点。
Clin Rev Allergy Immunol. 2018 Feb;54(1):147-176. doi: 10.1007/s12016-017-8654-z.
无皮肤病变的史蒂文斯-约翰逊综合征(富克斯综合征):支原体所致成人病例的文献综述
Arch Dermatol. 2012 Aug;148(8):963-4. doi: 10.1001/archdermatol.2012.681.
4
Fuchs syndrome associated with Mycoplasma pneumoniae (Stevens-Johnson syndrome without skin lesions).与肺炎支原体相关的富克斯综合征(无皮肤病变的史蒂文斯-约翰逊综合征)
Pediatr Dermatol. 2011 Jul-Aug;28(4):474-6. doi: 10.1111/j.1525-1470.2010.01200.x. Epub 2010 Jul 29.
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