用阿那白滞素治疗慢性自身免疫性脑膜脑炎和周期性发热综合征。
Chronic Autoimmune Meningoencephalitis and Periodic Fever Syndrome Treated with Anakinra.
作者信息
Novroski Alyssa-Rae, Baldwin Kelly J
机构信息
Department of Neurology, Geisinger Medical Center, Danville, Pennsylvania, USA.
出版信息
Case Rep Neurol. 2017 May 5;9(1):91-97. doi: 10.1159/000472147. eCollection 2017 Jan-Apr.
Abstract
We report the case of a 63-year-old male diagnosed with chronic autoimmune mediated meningoencephalitis and periodic cyclical fever syndrome. After 2 years of failed conventional treatment and recurrent hospitalizations, anakinra treatment (an interleukin-1 [IL-1] receptor antagonist) was trialed which resulted in full recovery. As evidenced by this case, anakinra can be used to treat chronic autoimmune meningitis, which can often be refractory to treatment.
摘要
我们报告了一例63岁男性患者，诊断为慢性自身免疫介导的脑膜脑炎和周期性循环发热综合征。在传统治疗失败且反复住院2年后，试用了阿那白滞素治疗（一种白细胞介素-1 [IL-1] 受体拮抗剂），结果患者完全康复。以此病例为证，阿那白滞素可用于治疗慢性自身免疫性脑膜炎，而这种疾病通常治疗困难。
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