Neokleous Antonis, Psarelis Savvas, Parperis Konstantinos M
Internal Medicine, University of Cyprus Medical School, Nicosia, CYP.
Division of Rheumatology, Nicosia General Hospital, Nicosia, CYP.
Cureus. 2020 May 22;12(5):e8244. doi: 10.7759/cureus.8244.
Autoinflammatory diseases (ADs) refer to a group of disorders of the innate immune system, mainly monogenic, marked by episodes of systemic inflammation. Aseptic meningitis is a rare neurological manifestation of ADs characterized by meningeal inflammation, negative routine cultures in the cerebrospinal fluid and identical signs and symptoms of bacterial meningitis. Herein, the aim of this review article is to describe the association between aseptic meningitis and ADs, especially in patients with familial Mediterranean fever (FMF) and chronic infantile neurological cutaneous articular (CINCA) syndrome. We will discuss the emerging role of proinflammatory cytokines, such as interleukin 1 (IL-1), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α), in the pathogenesis of aseptic meningitis in ADs, and will explore recent treatment developments, such as the use of biological agents.
自身炎症性疾病(ADs)是指一组先天性免疫系统疾病,主要为单基因疾病,其特征是全身性炎症发作。无菌性脑膜炎是ADs一种罕见的神经学表现,其特征为脑膜炎症、脑脊液常规培养阴性以及具有与细菌性脑膜炎相同的体征和症状。本文的目的是描述无菌性脑膜炎与ADs之间的关联,尤其是在家族性地中海热(FMF)和慢性婴儿神经皮肤关节综合征(CINCA)患者中。我们将讨论促炎细胞因子,如白细胞介素1(IL-1)、白细胞介素6(IL-6)和肿瘤坏死因子-α(TNF-α)在ADs无菌性脑膜炎发病机制中的新作用,并探讨近期的治疗进展,如生物制剂的使用。