重探癌症的特征
Revisiting the hallmarks of cancer.
作者信息
Fouad Yousef Ahmed, Aanei Carmen
机构信息
Faculty of Medicine, Ain Shams UniversityCairo, Egypt.
Hematology Laboratory, Pole De Biologie-Pathologie, University Hospital of St EtienneSt Etienne, France.
出版信息
Am J Cancer Res. 2017 May 1;7(5):1016-1036. eCollection 2017.
Abstract
The hallmarks of cancer described by Hanahan and Weinberg have proved seminal in our understanding of cancer's common traits and in rational drug design. Not free of critique and with understanding of different aspects of tumorigenesis coming into clearer focus in the recent years, we attempt to draw a more organized and updated picture of the cancer hallmarks. We define seven hallmarks of cancer: selective growth and proliferative advantage, altered stress response favoring overall survival, vascularization, invasion and metastasis, metabolic rewiring, an abetting microenvironment, and immune modulation, while highlighting some considerations for the future of the field.
摘要
事实证明，哈纳汉和温伯格所描述的癌症特征在我们对癌症共同特征的理解以及合理的药物设计方面具有开创性意义。尽管并非毫无争议，且近年来对肿瘤发生不同方面的理解日益清晰，但我们试图勾勒出一幅更有条理且更新的癌症特征图景。我们定义了癌症的七个特征：选择性生长和增殖优势、有利于整体生存的应激反应改变、血管生成、侵袭和转移、代谢重编程、支持性微环境以及免疫调节，同时强调了该领域未来的一些考量因素。
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本文引用的文献
1
Cancer Implications for Patients with Endometriosis.
Semin Reprod Med. 2017 Jan;35(1):110-116. doi: 10.1055/s-0036-1597120. Epub 2017 Jan 3.
2
Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.
Cancer Cell. 2017 Jan 9;31(1):142-156. doi: 10.1016/j.ccell.2016.11.011. Epub 2016 Dec 22.
3
Autophagy-Dependent Secretion: Contribution to Tumor Progression.
Front Oncol. 2016 Nov 25;6:251. doi: 10.3389/fonc.2016.00251. eCollection 2016.
4
Altered metabolite levels in cancer: implications for tumour biology and cancer therapy.
Nat Rev Cancer. 2016 Nov;16(11):680-693. doi: 10.1038/nrc.2016.85. Epub 2016 Sep 23.
5
The multifaceted roles of fatty acid synthesis in cancer.
Nat Rev Cancer. 2016 Nov;16(11):732-749. doi: 10.1038/nrc.2016.89. Epub 2016 Sep 23.
6
Serine and one-carbon metabolism in cancer.
Nat Rev Cancer. 2016 Oct;16(10):650-62. doi: 10.1038/nrc.2016.81. Epub 2016 Sep 16.
7
Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?
Nat Rev Cancer. 2016 Oct;16(10):635-49. doi: 10.1038/nrc.2016.77. Epub 2016 Sep 16.
8
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.
Science. 2016 Sep 9;353(6304):1161-5. doi: 10.1126/science.aaf5171.
9
Autophagy in cancer metastasis.
Oncogene. 2017 Mar 23;36(12):1619-1630. doi: 10.1038/onc.2016.333. Epub 2016 Sep 5.
10
The metabolic fate of acetate in cancer.
Nat Rev Cancer. 2016 Nov;16(11):708-717. doi: 10.1038/nrc.2016.87. Epub 2016 Aug 26.
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