Badhwar AmanPreet, Tam Angela, Dansereau Christian, Orban Pierre, Hoffstaedter Felix, Bellec Pierre
Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Montreal, Quebec, Canada.
Université de Montréal, Montreal, Quebec, Canada.
Alzheimers Dement (Amst). 2017 Apr 18;8:73-85. doi: 10.1016/j.dadm.2017.03.007. eCollection 2017.
We performed a systematic review and meta-analysis of the Alzheimer's disease (AD) literature to examine consistency of functional connectivity alterations in AD dementia and mild cognitive impairment, using resting-state functional magnetic resonance imaging.
Studies were screened using a standardized procedure. Multiresolution statistics were performed to assess the spatial consistency of findings across studies.
Thirty-four studies were included (1363 participants, average 40 per study). Consistent alterations in connectivity were found in the default mode, salience, and limbic networks in patients with AD dementia, mild cognitive impairment, or in both groups. We also identified a strong tendency in the literature toward specific examination of the default mode network.
Convergent evidence across the literature supports the use of resting-state connectivity as a biomarker of AD. The locations of consistent alterations suggest that highly connected hub regions in the brain might be an early target of AD.
我们对阿尔茨海默病（AD）相关文献进行了系统综述和荟萃分析，以使用静息态功能磁共振成像检查AD痴呆和轻度认知障碍中功能连接改变的一致性。
采用标准化程序筛选研究。进行多分辨率统计以评估各研究结果的空间一致性。
纳入了34项研究（1363名参与者，每项研究平均40名）。在AD痴呆患者、轻度认知障碍患者或两组患者中，默认模式网络、突显网络和边缘系统网络的连接性均出现了一致的改变。我们还在文献中发现了对默认模式网络进行特定检查的强烈趋势。
文献中的趋同证据支持将静息态连接性用作AD的生物标志物。一致改变的位置表明大脑中高度连接的枢纽区域可能是AD的早期靶点。
