纯二十碳五烯酸喂养对自发性高血压大鼠血压和血管反应性的影响。

Effect of pure eicosapentaenoic acid feeding on blood pressure and vascular reactivity in spontaneously hypertensive rats.

Yin K, Croft K D, Beilin L J

University Department of Medicine, Royal Perth Hospital, Western Australia.

Clin Exp Pharmacol Physiol. 1988 Apr;15(4):275-80. doi: 10.1111/j.1440-1681.1988.tb01072.x.

Abstract

This study examined the effects of eicosapentaenoic acid (EPA) treatment on vascular reactivity and blood pressure in spontaneously hypertensive rats (SHR). 2. Twenty SHR were given pure EPA as the methyl ester (280 mg/kg) by gavage for 10 days. An equal number of control rats received vehicle alone. EPA treatment had no effect on blood pressure compared with control rats. 3. Aortic rings from EPA-treated rats, precontracted with PGF2 alpha showed increased endothelium-dependent relaxations to acetylcholine. Endothelium-independent relaxations to sodium nitroprusside were not altered. Rings from rats fed pure EPA did not show any differences in vasoconstrictor responses to noradrenaline or serotonin. 4. Serum thromboxane B2 (TXB2) levels fell 17% in animals given pure EPA, but prostacyclin production was not affected. These responses are less than those seen following Max EPA fish oil. 5. Thus, pure EPA treatment did not lower blood pressure, but may have a direct effect on aortic endothelia and cause increased endothelium-dependent relaxations in response to acetylcholine in SHR.

摘要

本研究检测了二十碳五烯酸（EPA）治疗对自发性高血压大鼠（SHR）血管反应性和血压的影响。2. 二十只SHR通过灌胃给予纯EPA甲酯（280毫克/千克），持续10天。同等数量的对照大鼠仅接受赋形剂。与对照大鼠相比，EPA治疗对血压无影响。3. 用前列腺素F2α预收缩的EPA治疗大鼠的主动脉环，对乙酰胆碱的内皮依赖性舒张反应增强。对硝普钠的非内皮依赖性舒张反应未改变。喂食纯EPA的大鼠的主动脉环对去甲肾上腺素或5-羟色胺的血管收缩反应未显示任何差异。4. 给予纯EPA的动物血清血栓素B2（TXB2）水平下降了17%，但前列环素的生成未受影响。这些反应小于服用Max EPA鱼油后的反应。5. 因此，纯EPA治疗并未降低血压，但可能对主动脉内皮有直接作用，并导致SHR对乙酰胆碱的内皮依赖性舒张反应增强。