Schiffer C A, Aisner J, Daly P A, Wiernik P H
Am J Med. 1979 Mar;66(3):519-22. doi: 10.1016/0002-9343(79)91093-3.
Neutrophils from a patient with chronic myelogenous leukemia and typically low leukocyte alkaline phosphatase (LAP) activity markedly increased in LAP content following transfusion to and circulation in an infected neutropenic recipient. Incubation of the recipient's serum and plasma with normal neutrophils failed to alter their LAP activity. This observation suggests that LAP activity is inducible by as yet unknown "environmental" factors, and possible mechanisms for this are discussed.
一名慢性粒细胞白血病患者的中性粒细胞通常具有较低的白细胞碱性磷酸酶（LAP）活性，在输注给一名感染性中性粒细胞减少的受体并在其循环系统中后，其LAP含量显著增加。将受体的血清和血浆与正常中性粒细胞一起孵育未能改变它们的LAP活性。这一观察结果表明，LAP活性可被尚不清楚的“环境”因素诱导，并讨论了其可能的机制。
