双嘧达莫对内毒素血症小鼠血糖、肝脏环磷酸腺苷水平及血小板计数的影响

Effect of dipyridamole on blood glucose and liver cyclic AMP levels and platelet count during endotoxaemia in mice.

Al-Jibouri L M, Najim R A

Department of Pharmacology, College of Medicine, Baghdad University, Iraq.

Clin Exp Pharmacol Physiol. 1988 Jul;15(7):527-32. doi: 10.1111/j.1440-1681.1988.tb01110.x.

Abstract

Blood glucose, liver cyclic AMP (cAMP) levels, and platelet count were studied at different times during a 12 h interval after intravenous (i.v.) endotoxin injection (40 mg/kg) in mice. 2. Blood glucose and liver cAMP levels showed a progressive decrease in endotoxic mice and the decrease was significant after 8 and 12 h. 3. Dipyridamole (50 mg/kg) administered intraperitoneally (i.p.) 7 h post-endotoxin improved blood glucose and liver cAMP levels. 4. Platelet counts were decreased after 1 h in endotoxic mice and remained decreased up to 8 h. Dipyridamole administered soon after endotoxin improved platelet counts in endotoxic mice and increased survival rate to 100%.

摘要

在给小鼠静脉注射（i.v.）内毒素（40mg/kg）后的12小时间隔内，在不同时间点研究了血糖、肝脏环磷酸腺苷（cAMP）水平和血小板计数。2. 内毒素血症小鼠的血糖和肝脏cAMP水平呈逐渐下降趋势，在8小时和12小时后下降显著。3. 在内毒素注射后7小时腹腔注射（i.p.）双嘧达莫（50mg/kg）可改善血糖和肝脏cAMP水平。4. 内毒素血症小鼠在1小时后血小板计数下降，直至8小时仍保持下降。内毒素注射后不久给予双嘧达莫可改善内毒素血症小鼠的血小板计数，并将存活率提高至100%。