Zhang Julei, Li Yan, Bai Xiaozhi, Li Yuehua, Shi Jihong, Hu Dahai
Department of Burns and Cutaneous Surgery, Xijing Hospital, the Fourth Military Medical University, Xi' an, Shanxi, China.
Histol Histopathol. 2018 Jan;33(1):27-39. doi: 10.14670/HH-11-908. Epub 2017 May 31.
Hypertrophic scars (HTS) are predominant diseases after burn and trauma, which cause severe physiological and psychological problems. HTS have been researched for decades, and our knowledge about the mechanisms of HTS formation process has been increasing. However, the effects of currently available prevention and treatment strategies are limited. In this review, we summarize currently known mechanisms and recent studies of HTS, including extracellular matrix, matrix metalloproteinases, fibroblasts, myofibroblasts and their contraction ability, keratinocytes, growth factors, inflammatory and immune response, and stem cell treatment, hoping for a better understanding of HTS generation, development and effective translation to treatment strategies.
增生性瘢痕（HTS）是烧伤和创伤后的主要疾病，会导致严重的生理和心理问题。对增生性瘢痕的研究已有数十年，我们对其形成过程机制的了解也在不断增加。然而，目前可用的预防和治疗策略效果有限。在本综述中，我们总结了目前已知的增生性瘢痕机制和近期研究，包括细胞外基质、基质金属蛋白酶、成纤维细胞、肌成纤维细胞及其收缩能力、角质形成细胞、生长因子、炎症和免疫反应以及干细胞治疗，希望能更好地理解增生性瘢痕的发生、发展，并有效地转化为治疗策略。
