Mannino R J, Gould-Fogerite S
Dept. of Microbiology & Immunology, Albany Medical College, New York 12208.
Biotechniques. 1988 Jul-Aug;6(7):682-90.
Liposomes, artificial membrane vesicles, are being intensively studied for their usefulness as delivery vehicles in vitro and in vivo. Substantial progress has been made in the development of procedures for liposome preparation, targeting and delivery of contents. The broad flexibility now available in the design of the structure and composition of liposomes, coupled to recent reports of liposome mediated gene transfer in animals, suggest that liposome technology is now poised to be utilized in the creation of custom-designed cell-type-specific gene transfer vehicles.
脂质体,即人工膜泡,正因其作为体内外递送载体的效用而受到深入研究。在脂质体制备、靶向及内容物递送程序的开发方面已取得了重大进展。目前脂质体结构和组成设计具有广泛的灵活性,再加上近期有关脂质体介导动物基因转移的报道,这表明脂质体技术现已准备好用于创建定制的细胞类型特异性基因转移载体。