• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma.

作者信息

Hatada I, Tokino T, Ochiya T, Matsubara K

机构信息

Institute for Molecular and Cellular Biology, Osaka University, Japan.

出版信息

Oncogene. 1988 Nov;3(5):537-40.

PMID:2856253
Abstract

Transforming activity was detected in a hepatocellular carcinoma (HCC) carrying four integrated hepatitis B virus (HBV) DNA. This transforming gene was identified as hst-1, that lies in chromosome 11, band q13.3. One of the integrated HBV DNAs was found to lie close to the hst-1, and the hst-1 and the integrated HBV DNA were found to be co-amplified. The region of the amplification was limited. A model has been proposed that correlates the viral integration, amplification and activation of an oncogene.

摘要

相似文献

1
Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma.
Oncogene. 1988 Nov;3(5):537-40.
2
[Hepatitis B virus integration and oncogene activation].[乙肝病毒整合与癌基因激活]
Gan To Kagaku Ryoho. 1987 Jun;14(6 Pt 2):2152-63.
3
Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas.乙型肝炎病毒在靠近p53基因的人类17号染色体p臂上的整合事件，确定了在病毒阳性肝细胞癌中常见的染色体缺失区域。
Cancer Res. 1991 Jan 1;51(1):49-54.
4
[Molecular aspects of human hepatocellular carcinoma].
Gan To Kagaku Ryoho. 1989 Jan;16(1):18-24.
5
Expression profile of nine novel genes differentially expressed in hepatitis B virus-associated hepatocellular carcinomas.9个在乙型肝炎病毒相关肝细胞癌中差异表达的新基因的表达谱
Oncogene. 2001 Jul 27;20(33):4568-75. doi: 10.1038/sj.onc.1204626.
6
Transforming DNA sequences of human hepatocellular carcinomas, their distribution and relationship with hepatitis B virus sequence in human hepatomas.
Leukemia. 1988 Dec;2(12 Suppl):102S-113S.
7
Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma.乙型肝炎病毒作为人类肝细胞癌中的一种插入诱变剂。
Mol Biol Med. 1990 Jun;7(3):213-22.
8
[Identification of hepatitis B virus integration sites in hepatocellular carcinoma tissues from patients with chronic hepatitis B].[慢性乙型肝炎患者肝细胞癌组织中乙型肝炎病毒整合位点的鉴定]
Zhonghua Yi Xue Za Zhi. 2006 May 16;86(18):1249-52.
9
Hepatitis B virus and hepatocellular carcinoma: molecular biology and mechanistic considerations.
Semin Liver Dis. 1984 May;4(2):98-112. doi: 10.1055/s-2008-1040650.
10
[Relationship between mutation on precore region of integrated HBV DNA and p53 gene mutation in hepatocellular carcinoma].[整合型乙肝病毒脱氧核糖核酸前核心区突变与肝细胞癌中p53基因突变的关系]
Ai Zheng. 2003 Jul;22(7):715-8.

引用本文的文献

1
Re-analysis of hepatitis B virus integration sites reveals potential new loci associated with oncogenesis in hepatocellular carcinoma.对乙肝病毒整合位点的重新分析揭示了与肝细胞癌肿瘤发生相关的潜在新基因座。
World J Virol. 2023 Jun 25;12(3):209-220. doi: 10.5501/wjv.v12.i3.209.
2
HBV Integration Induces Complex Interactions between Host and Viral Genomic Functions at the Insertion Site.乙肝病毒整合在插入位点诱导宿主与病毒基因组功能之间的复杂相互作用。
J Clin Transl Hepatol. 2021 Jun 28;9(3):399-408. doi: 10.14218/JCTH.2021.00062. Epub 2021 Apr 25.
3
Amplification and overexpression of the EMS 1 oncogene, a possible prognostic marker, in human hepatocellular carcinoma.
EMS 1致癌基因在人类肝细胞癌中的扩增与过表达，EMS 1致癌基因可能是一种预后标志物。
J Mol Diagn. 2003 Feb;5(1):48-53. doi: 10.1016/S1525-1578(10)60451-5.
4
Double-stranded linear duck hepatitis B virus (DHBV) stably integrates at a higher frequency than wild-type DHBV in LMH chicken hepatoma cells.双链线性鸭乙型肝炎病毒（DHBV）在LMH鸡肝癌细胞中的整合频率高于野生型DHBV，且整合稳定。
J Virol. 1999 Feb;73(2):1492-502. doi: 10.1128/JVI.73.2.1492-1502.1999.
5
Cyclin D1 and human neoplasia.细胞周期蛋白D1与人类肿瘤
Mol Pathol. 1998 Feb;51(1):1-7. doi: 10.1136/mp.51.1.1.
6
Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma.乙型肝炎病毒X抗原在慢性感染发病机制及肝细胞癌发生发展中的作用
Am J Pathol. 1997 Apr;150(4):1141-57.
7
Different patterns of DNA alterations detected by restriction landmark genomic scanning in heterogeneous prostate carcinomas.通过限制性内切酶图谱基因组扫描在异质性前列腺癌中检测到的不同DNA改变模式。
Am J Pathol. 1997 Jan;150(1):305-14.
8
Loss and acquisition of duck hepatitis B virus integrations in lineages of LMH-D2 chicken hepatoma cells.LMH-D2鸡肝癌细胞系中鸭乙型肝炎病毒整合的丢失与获得
J Virol. 1996 Mar;70(3):2000-7. doi: 10.1128/JVI.70.3.2000-2007.1996.
9
Chromosome 11q13 markers and D-type cyclins in breast cancer.
Breast Cancer Res Treat. 1995;33(2):125-35. doi: 10.1007/BF00682720.
10
Overexpression and localization of cyclin D1 mRNA and antigen in esophageal cancer.细胞周期蛋白D1 mRNA及抗原在食管癌中的过表达与定位
Am J Pathol. 1995 May;146(5):1161-9.