Ostrow R S, Bender M E
Department of Microbiology, University of Minnesota Medical School, Minneapolis.
Adv Dermatol. 1986;1:223-35.
Recombinant DNA technology has enabled investigators to understand papillomavirus biology. HPV DNA has been found in a variety of benign and malignant tumors. Once discovered, this HPV DNA can be extracted, produced in large quantities, and submitted to nucleotide sequence analysis. Ultimately, this research should reveal the mechanism(s) involved in the malignant transformation of HPV-induced papillomas. It may also help us produce a genetically engineered, safe vaccine against the HPV.
重组DNA技术使研究人员能够了解乳头瘤病毒生物学。人们已在多种良性和恶性肿瘤中发现了人乳头瘤病毒(HPV)DNA。一旦发现这种HPV DNA,就可以将其提取、大量生产并进行核苷酸序列分析。最终,这项研究应能揭示HPV诱导的乳头状瘤恶性转化所涉及的机制。它或许还能帮助我们生产出一种针对HPV的基因工程安全疫苗。