Perilongo G, Carli M, Guglielmi M, De Bernardi B, Bellani F F, Paolucci G, Pianca C, Madon E, Calculli G, Ceci A
Division of Pediatric Oncology-Hematology, University of Padua, Italy.
Pediatr Hematol Oncol. 1987;4(3):179-88. doi: 10.3109/08880018709141269.
We analyzed the clinical features and treatment of 23 hepatoblastomas (HPBs) and 16 hepatocellular carcinomas (HPCs) occurring in patients less than 19 years old, admitted to the Italian retrospective multicentric study, conducted between 1983 and 1985, on childhood malignant hepatic tumors. The median ages of the patients with HPB and HPC at diagnosis were 22.34 months and 96.23 months, respectively, with a male/female ratio of 0.7 and 1.7, respectively. Fourteen HPBs (61%) and 5 HPCs (31%) achieved surgical complete remission (CR). Of these, 11 HPB and all 5 HPC are still in CR with a median follow-up of 36 months and 3.5 years, respectively. One HPB and 1 HPC became resectable after a primary course of cis-platinum alone in the case of HPB and used with VP-16 in the case of HPC. All of the 9 HPBs and 11 HPCs, who never achieved CR, died of disease at a median interval from diagnosis of 5 and 2 months, respectively. The published therapeutic approaches for these tumors were also reviewed.
我们分析了1983年至1985年间在意大利进行的一项关于儿童恶性肝肿瘤的回顾性多中心研究中，19岁以下患者发生的23例肝母细胞瘤（HPB）和16例肝细胞癌（HPC）的临床特征及治疗情况。HPB和HPC患者诊断时的中位年龄分别为22.34个月和96.23个月，男女比例分别为0.7和1.7。14例HPB（61%）和5例HPC（31%）实现了手术完全缓解（CR）。其中，11例HPB和所有5例HPC仍处于CR状态，中位随访时间分别为36个月和3.5年。1例HPB和1例HPC在单独使用顺铂进行初始疗程后（HPB病例）或与VP - 16联合使用后（HPC病例）变得可切除。9例未实现CR的HPB和11例未实现CR的HPC均死于疾病，从诊断开始的中位间隔时间分别为5个月和2个月。我们还回顾了这些肿瘤已发表的治疗方法。
