Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
Autoimmun Rev. 2017 Aug;16(8):845-855. doi: 10.1016/j.autrev.2017.05.016. Epub 2017 May 28.
Survivin is a protein functionally important for cell division, apoptosis, and possibly, for micro-RNA biogenesis. It is an established marker of malignant cell transformation. In non-malignant conditions, the unique properties of survivin make it indispensable for homeostasis of the immune system. Indeed, it is required for the innate and adaptive immune responses, controlling differentiation and maintenance of CD4 and CD8 memory T-cells, and in B cell maturation. Recently, survivin has emerged as an important player in the pathogenesis of autoimmune diseases. Under the conditions of unreserved inflammation, survivin enhances antigen presentation, maintains persistence of autoreactive cells, and supports production of autoantibodies. In this context, survivin takes its place as a diagnostic and prognostic marker in rheumatoid arthritis, psoriasis, systemic sclerosis and pulmonary arterial hypertension, neuropathology and multiple sclerosis, inflammatory bowel diseases and oral lichen planus. In this review, we summarise the knowledge about non-malignant properties of survivin and focus on its engagement in cellular and molecular pathology of autoimmune diseases. The review highlights utility of survivin measures for clinical applications. It provides rational for the survivin inhibiting strategies and presents results of recent reports on survivin inhibition in modern therapies of cancers and autoimmune diseases.
生存素是一种对细胞分裂、细胞凋亡以及微 RNA 生物发生具有重要功能的蛋白质。它是恶性细胞转化的公认标志物。在非恶性条件下，生存素的独特特性使其成为免疫系统稳态所必需的。事实上，它对于先天和适应性免疫反应、控制 CD4 和 CD8 记忆 T 细胞的分化和维持以及 B 细胞成熟都是必不可少的。最近，生存素已成为自身免疫性疾病发病机制中的重要参与者。在不受限制的炎症条件下，生存素增强抗原呈递、维持自身反应性细胞的持久性，并支持自身抗体的产生。在这种情况下，生存素在类风湿关节炎、银屑病、系统性硬化症和肺动脉高压、神经病理学和多发性硬化症、炎症性肠病和口腔扁平苔藓中作为诊断和预后标志物。在这篇综述中，我们总结了生存素的非恶性特性的知识，并重点介绍了它在自身免疫性疾病的细胞和分子病理学中的参与。该综述强调了生存素测量在临床应用中的实用性。它为生存素抑制策略提供了依据，并介绍了最近关于生存素抑制在癌症和自身免疫性疾病现代治疗中的报告结果。
