Mattern J, Wayss K, Volm M
German Cancer Research Center, Institute of Experimental Pathology, Heidelberg.
In Vivo. 1987 Jan-Feb;1(1):23-6.
In order to establish the usefulness of the nude-mouse human tumour xenograft system as a predictive screen for antineoplastic agents, the antitumour activity of cyclophosphamide (CTX) and cisplatin (DDP), two clinically active drugs, was tested against a panel of 14 human non-small cell lung tumour xenografts and the experimental results were compared with the clinical results reported in the literature. The poor clinical response of non-small cell tumours was reflected in the lack of response of the xenograft tumours to these two agents.
为了确定裸鼠人肿瘤异种移植系统作为抗肿瘤药物预测筛选模型的实用性，对环磷酰胺（CTX）和顺铂（DDP）这两种临床活性药物针对14种人非小细胞肺癌异种移植瘤的抗肿瘤活性进行了测试，并将实验结果与文献报道的临床结果进行了比较。非小细胞肿瘤较差的临床反应在异种移植瘤对这两种药物缺乏反应中得到了体现。
