Lenormand Thomas, Guillemaud Thomas, Bourguet Denis, Raymond Michel
Laboratoire Génétique et Environnement, Institut des Sciences de l'Evolution (UMR 5554), Université Montpellier II, 34095, Montpellier Cedex 5, France.
Evolution. 1998 Dec;52(6):1705-1712. doi: 10.1111/j.1558-5646.1998.tb02250.x.
Evolution of a new gene function is a fundamental process of adaptation. Gene duplication followed by divergence due to relaxed selection on redundant copies has been viewed as the predominant mechanism involved in this process. At a macroevolutionary scale, evidence for this scenario came from the analysis of sequences of genes families. However, even if several genetic models have described the different potential microevolutionary scenario for a new function to evolve, little is really known about the initial evolutionary dynamics of such processes. We analyze such early dynamics in natural populations of the mosquito Culex pipiens polymorphic for a duplication at Ace.1, a locus involved in insecticide resistance. The date of occurrence and the selective advantages of the duplication were estimated using frequency data. We propose a scenario where the spread of a duplication is driven, from the very beginning, by selection due to insecticide treatment.
新基因功能的进化是适应的一个基本过程。基因复制后，由于对冗余拷贝的选择放松而发生分化，这被视为该过程中涉及的主要机制。在宏观进化尺度上，这一情况的证据来自对基因家族序列的分析。然而，即使有几种遗传模型描述了新功能进化的不同潜在微观进化情况，但对于此类过程的初始进化动态，人们实际上知之甚少。我们分析了淡色库蚊自然种群中Ace.1位点重复多态性的早期动态，Ace.1位点与杀虫剂抗性有关。利用频率数据估计了重复发生的日期和选择优势。我们提出了一种情况，即重复的传播从一开始就受到杀虫剂处理导致的选择驱动。
