Bergström M, Mosskin M, Ericson K, Ehrin E, Thorell J O, von Holst H, Norén G, Persson A, Halldin C, Stone-Elander S
Department of Neuroradiology, Karolinska Sjukhuset, Stockholm, Sweden.
Acta Radiol Suppl. 1986;369:409-11.
A specific ligand for peripheral type benzodiazepine receptors, Ro5-4864, was synthesised and labelled with 11C for use in positron emission tomography (PET). Four patients with suspected glioma, two patients with high grade astrocytoma and two with low grade astrocytoma, as well as one patient with meningioma were examined with PET after the administration of 200 MBq 11C-Ro5-4864. The images as well as kinetic analyses revealed lower uptake of the ligand in tumor as compared with cortical tissue. Markedly elevated uptake in the thalamus suggests a functional role of the ligand.
合成了外周型苯二氮䓬受体的特异性配体Ro5-4864，并用11C进行标记，用于正电子发射断层扫描（PET）。对4例疑似胶质瘤患者（2例高级别星形细胞瘤患者和2例低级别星形细胞瘤患者）以及1例脑膜瘤患者，在给予200 MBq 11C-Ro5-4864后进行PET检查。图像及动力学分析显示，与皮质组织相比，肿瘤中该配体的摄取较低。丘脑摄取明显升高表明该配体具有功能作用。
