摄入标记的维生素和矿物质补充剂后人体对硒（75Se）、锌（65Zn）和锰（54Mn）的保留情况。

Retention of selenium (75Se), Zinc (65Zn) and manganese (54Mn) in humans after intake of a labelled vitamin and mineral supplement.

作者信息

Sandström B, Davidsson L, Eriksson R, Alpsten M, Bogentoft C

机构信息

Department of Clinical Nutrition, University of Gothenburg, Sahlgrenska Hospital, Sweden.

出版信息

J Trace Elem Electrolytes Health Dis. 1987 Sep;1(1):33-8.

PMID:2856562

Abstract

The whole body retention of 75Se, 65Zn, and 54Mn after intake of a labelled vitamin and mineral supplement was followed in 12 healthy volunteers. The supplement had a vitamin and mineral content according to recommended dietary allowances or the so-called "safe and adequate levels" for trace elements, including 15 mg of zinc as zinc citrate, 50 micrograms of selenium as sodium selenite and 2.5 mg of manganese as manganese sulphate. The supplement was taken either in the fasting state or together with a light meal. Retention day 14 was 48 +/- 6%, 33 +/- 6% and 5 +/- 2% (mean +/- SD) for selenium, zinc and manganese, respectively, when the supplement was taken fasting and 45 +/- 3%, 8 +/- 1% and 1.0 +/- 0.2% when it was taken with food. During day 1-14, 27%, 1% and less than 0.01% of the administered selenium, zinc and manganese radionuclides, respectively, were excreted in the urine. Based on the rate of turnover of the radionuclides and the urinary losses of 75Se, the absorption of selenium, zinc and manganese from the supplement was estimated to be 89 +/- 5%, 38 +/- 7%, 9 +/- 3% (mean +/- SD) in the fasting state and 87 +/- 4%, 10 +/- 2% and 2 +/- 1% with food. These results indicate that when a supplement is taken with food the minerals are absorbed and metabolized in the same way as are native minerals in food. When the supplement is taken in the fasting state, the absorption of zinc and manganese can be substantially higher.

摘要

在12名健康志愿者中，跟踪了摄入标记维生素和矿物质补充剂后75Se、65Zn和54Mn在全身的滞留情况。该补充剂的维生素和矿物质含量符合推荐膳食摄入量或微量元素的所谓“安全充足水平”，包括15毫克柠檬酸锌形式的锌、50微克亚硒酸钠形式的硒和2.5毫克硫酸锰形式的锰。补充剂在空腹状态下服用或与清淡食物一起服用。当补充剂空腹服用时，第14天硒、锌和锰的滞留率分别为48±6%、33±6%和5±2%（平均值±标准差），与食物一起服用时分别为45±3%、8±1%和1.0±0.2%。在第1 - 14天期间，分别有27%、1%和小于0.01%的摄入硒、锌和锰放射性核素经尿液排出。根据放射性核素的周转速率和75Se的尿液损失情况，估计补充剂中硒、锌和锰在空腹状态下的吸收率分别为89±5%、38±7%、9±3%（平均值±标准差），与食物一起服用时分别为87±4%、10±2%和2±1%。这些结果表明，当补充剂与食物一起服用时，矿物质的吸收和代谢方式与食物中天然矿物质相同。当补充剂在空腹状态下服用时，锌和锰的吸收率可能会显著更高。