Comeau Patricia, Filiaggi Mark
Department of Applied Oral Sciences, Dalhousie University, Halifax, Canada.
J Biomater Appl. 2017 Jul;32(1):126-136. doi: 10.1177/0885328217708639. Epub 2017 May 31.
Local delivery systems have taken on a greater clinical focus for osteomyelitis therapy owing to their ability to overcome many disadvantages of systemic delivery. This study reports for the first time the capacity to fabricate strontium- and vancomycin-doped calcium polyphosphate beads using a two-stage cold isostatic pressing and gelling approach. The fabricated beads were of uniform shape and diameter, and upon gelling exhibited reduced porosity. Of greatest significance in the subsequent in vitro study was the improvement of bead long-term structural stability upon vancomycin incorporation; a characteristic that further encourages the extended release of therapeutically relevant levels of antibiotic. Overall, this study provides support for the inclusion of a cold isostatic pressing step in the fabrication of a therapeutically loaded calcium polyphosphate bead-based local delivery system intended for osteomyelitis treatment.
由于局部给药系统能够克服全身给药的许多缺点，因此在骨髓炎治疗中受到了更多的临床关注。本研究首次报道了使用两阶段冷等静压和胶凝方法制备锶和万古霉素掺杂的聚磷酸钙珠的能力。所制备的珠子形状和直径均匀，胶凝后孔隙率降低。在随后的体外研究中，最显著的是万古霉素掺入后珠子长期结构稳定性的提高；这一特性进一步促进了治疗相关水平抗生素的缓释。总体而言，本研究为在制备用于治疗骨髓炎的负载治疗剂的聚磷酸钙珠基局部给药系统中纳入冷等静压步骤提供了支持。
