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爱泼斯坦-巴尔病毒阳性葡萄膜炎后大脑中鼻型结外NK/T细胞淋巴瘤的发生

Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis.

作者信息

Imai Ayano, Takase Hiroshi, Imadome Ken-Ichi, Matsuda Go, Ohnishi Iichiro, Yamamoto Kouhei, Kudo Takumi, Tanaka Yoji, Maehara Taketoshi, Miura Osamu, Arai Ayako

机构信息

Department of Ophthalmology, Tokyo Medical and Dental University, Japan.

Division of Advanced Medicine for Virus Infections, National Research Institute for Child Health and Development, Japan.

出版信息

Intern Med. 2017;56(11):1409-1414. doi: 10.2169/internalmedicine.56.7573. Epub 2017 Jun 1.

DOI:10.2169/internalmedicine.56.7573
PMID:28566607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5498208/
Abstract

A 74-year-old woman developed bilateral uveitis with high Epstein-Barr virus (EBV) DNA load in the vitreous fluid without lymphoma cells. Four years after the onset, T2-weighted contrast-enhanced MRI revealed hyperintense lesions in the right occipital and parietal lobe. A biopsy resulted in the diagnosis of extranodal NK/T-cell lymphoma nasal type (ENKL). The repeat region of LMP1, an EBV gene, detected in the brain lesion was identical to that detected in the vitreous fluid. ENKL of the central nervous system is quite rare, and the pathogenesis has not been determined. The lymphoma in this case might have been closely associated with the EBV-positive uveitis.

摘要

一名74岁女性出现双侧葡萄膜炎，玻璃体液中EB病毒（EBV）DNA载量高且无淋巴瘤细胞。发病四年后，T2加权增强MRI显示右侧枕叶和顶叶有高信号病变。活检结果诊断为鼻型结外NK/T细胞淋巴瘤（ENKL）。在脑病变中检测到的EBV基因LMP1的重复区域与在玻璃体液中检测到的相同。中枢神经系统的ENKL非常罕见，其发病机制尚未确定。该病例中的淋巴瘤可能与EBV阳性葡萄膜炎密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1361/5498208/6fa0b301344f/1349-7235-56-1409-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1361/5498208/f45b12741b3a/1349-7235-56-1409-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1361/5498208/5bf21b80eb8b/1349-7235-56-1409-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1361/5498208/c1c81a6c004f/1349-7235-56-1409-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1361/5498208/6fa0b301344f/1349-7235-56-1409-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1361/5498208/f45b12741b3a/1349-7235-56-1409-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1361/5498208/5bf21b80eb8b/1349-7235-56-1409-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1361/5498208/c1c81a6c004f/1349-7235-56-1409-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1361/5498208/6fa0b301344f/1349-7235-56-1409-g004.jpg

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BMC Ophthalmol. 2015 Nov 19;15:169. doi: 10.1186/s12886-015-0158-0.
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Primary natural killer/T-cell lymphoma presenting as leptomeningeal disease.
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