Hosseini Seyedeh Maryam, Abrishami Mojtaba, Barashki Elham, Zamani Ghodsieh
Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Case Rep Ophthalmol Med. 2021 Oct 6;2021:9496173. doi: 10.1155/2021/9496173. eCollection 2021.
Herein, we report a case of primary intraocular lymphoma (PIOL) with the first presentation of bilateral Epstein-Barr virus- (EBV-) associated panuveitis. . A 69-year-old male was referred with a three-day history of blurred vision and pain and redness in his left eye following cataract surgery. Examination revealed panuveitis, vitritis, and necrotizing retinitis with retinal hemorrhage. A month later, the right eye was also involved. Polymerase chain reaction-based analysis of the vitreous sample was positive for EBV, and cytological evaluation was compatible with the diagnosis of B-cell lymphoma. A significant improvement was observed following serial intravitreal rituximab and methotrexate injections. The central nervous system and lungs were involved after 6 months, and the patient expired despite systemic chemotherapy.
There may be an association between EBV panuveitis and primary intraocular B-cell lymphoma.
在此，我们报告一例原发性眼内淋巴瘤（PIOL），首次表现为双侧 Epstein-Barr 病毒（EBV）相关的全葡萄膜炎。一名 69 岁男性因白内障手术后左眼视力模糊、疼痛和发红三天前来就诊。检查发现全葡萄膜炎、玻璃体炎和伴有视网膜出血的坏死性视网膜炎。一个月后，右眼也受到累及。基于聚合酶链反应的玻璃体样本分析显示 EBV 呈阳性，细胞学评估与 B 细胞淋巴瘤的诊断相符。在连续玻璃体内注射利妥昔单抗和甲氨蝶呤后观察到显著改善。6 个月后中枢神经系统和肺部受累，尽管进行了全身化疗，患者仍死亡。
EBV 全葡萄膜炎与原发性眼内 B 细胞淋巴瘤之间可能存在关联。
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