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一名患有双侧爱泼斯坦-巴尔病毒全葡萄膜炎患者的原发性眼内淋巴瘤

Primary Intraocular Lymphoma in a Patient with Bilateral Epstein-Barr Virus Panuveitis.

作者信息

Hosseini Seyedeh Maryam, Abrishami Mojtaba, Barashki Elham, Zamani Ghodsieh

机构信息

Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Case Rep Ophthalmol Med. 2021 Oct 6;2021:9496173. doi: 10.1155/2021/9496173. eCollection 2021.

DOI:10.1155/2021/9496173
PMID:34659852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8514923/
Abstract

PURPOSE

Herein, we report a case of primary intraocular lymphoma (PIOL) with the first presentation of bilateral Epstein-Barr virus- (EBV-) associated panuveitis. . A 69-year-old male was referred with a three-day history of blurred vision and pain and redness in his left eye following cataract surgery. Examination revealed panuveitis, vitritis, and necrotizing retinitis with retinal hemorrhage. A month later, the right eye was also involved. Polymerase chain reaction-based analysis of the vitreous sample was positive for EBV, and cytological evaluation was compatible with the diagnosis of B-cell lymphoma. A significant improvement was observed following serial intravitreal rituximab and methotrexate injections. The central nervous system and lungs were involved after 6 months, and the patient expired despite systemic chemotherapy.

CONCLUSION

There may be an association between EBV panuveitis and primary intraocular B-cell lymphoma.

摘要

目的

在此，我们报告一例原发性眼内淋巴瘤（PIOL），首次表现为双侧 Epstein-Barr 病毒（EBV）相关的全葡萄膜炎。一名 69 岁男性因白内障手术后左眼视力模糊、疼痛和发红三天前来就诊。检查发现全葡萄膜炎、玻璃体炎和伴有视网膜出血的坏死性视网膜炎。一个月后，右眼也受到累及。基于聚合酶链反应的玻璃体样本分析显示 EBV 呈阳性，细胞学评估与 B 细胞淋巴瘤的诊断相符。在连续玻璃体内注射利妥昔单抗和甲氨蝶呤后观察到显著改善。6 个月后中枢神经系统和肺部受累，尽管进行了全身化疗，患者仍死亡。

结论

EBV 全葡萄膜炎与原发性眼内 B 细胞淋巴瘤之间可能存在关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fb/8514923/c87712e61811/CRIOPM2021-9496173.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fb/8514923/f58e0b92c57b/CRIOPM2021-9496173.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fb/8514923/a6e7b799b984/CRIOPM2021-9496173.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fb/8514923/6574c1e6f008/CRIOPM2021-9496173.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fb/8514923/c87712e61811/CRIOPM2021-9496173.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fb/8514923/f58e0b92c57b/CRIOPM2021-9496173.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fb/8514923/a6e7b799b984/CRIOPM2021-9496173.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fb/8514923/6574c1e6f008/CRIOPM2021-9496173.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68fb/8514923/c87712e61811/CRIOPM2021-9496173.004.jpg

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