Ghione S, Rosa C, Panattoni E, Nuti M, Mezzasalma L, Giuliano G
CNR Clinical Physiology Institute, University of Pisa, Italy.
J Hypertens Suppl. 1985 Dec;3(3):S113-5.
Recent studies indicate a diminished responsiveness to noxious stimuli in arterial hypertension in the experimental animal. A similar finding is also reported in the only study published to our knowledge on this subject in man. The aim of the study was to assess in humans the sensory and pain threshold by a non-invasive tooth pulp stimulation test (stepwise increased electrical stimuli delivered by a commercial pulp tester). Subjects had to report when they started to feel pulp stimulation and when this became painful. The data reported are the means of the measurements on four healthy teeth in each subject. Significantly higher values (expressed as relative units [RU]) were found in 28 non-treated essential hypertensives compared with 33 normotensive controls for sensory threshold (40.64 +/- 8.07 versus 29.96 +/- 6.82 RU, P < 0.0001) and for pain threshold (55.67 +/- 12.74 versus 42.08 +/- 12.58 RU, P < 0.001). Multivariate analysis of variance showed that this difference was apparently not related to age and sex. These data lend further support to the view that pain modulation may be altered in the hypertensive state in man.
最近的研究表明，实验动物的动脉高血压对伤害性刺激的反应性降低。据我们所知，在已发表的关于该主题的唯一一项人体研究中也报告了类似的发现。本研究的目的是通过无创牙髓刺激试验（由商用牙髓测试仪逐步增加电刺激）评估人体的感觉阈值和疼痛阈值。受试者必须报告他们何时开始感觉到牙髓刺激以及何时这种刺激变得疼痛。报告的数据是每个受试者四颗健康牙齿测量值的平均值。与33名血压正常的对照组相比，28名未经治疗的原发性高血压患者的感觉阈值（40.64±8.07相对单位[RU]对29.96±6.82 RU，P<0.0001）和疼痛阈值（55.67±12.74对42.08±12.58 RU，P<0.001）显著更高。多变量方差分析表明，这种差异显然与年龄和性别无关。这些数据进一步支持了人类高血压状态下疼痛调节可能改变的观点。
