Stott D J, Robertson J I, Ball S G
MRC Blood Pressure Unit, Western Infirmary, Glasgow, UK.
J Hypertens Suppl. 1985 Dec;3(3):S191-3.
Ketanserin reduces blood pressure effectively, but without inducing tachycardia. Its precise mode of action is unclear but under some circumstances it attenuates the rise in blood pressure caused by infusion of the alpha 1-agonist phenylephrine, suggesting that it acts at least partly as an alpha 1-adrenoceptor antagonist. However, the specificity of this attenuation has been questioned. We have therefore examined the effects of ketanserin on the blood pressure and heart rate responses to angiotensin II (a vasoconstrictor agent largely devoid of alpha 1-agonist properties). The blood pressure response to infused angiotensin II, in contrast to that of phenylephrine, was not attenuated by ketanserin. Ketanserin appeared not to increase cardiac efferent parasympathetic activity. At a dose used in the treatment of hypertension, ketanserin produces alpha 1-antagonism in man, which may partly explain its antihypertensive effect.
酮色林能有效降低血压，但不会引起心动过速。其确切作用方式尚不清楚，但在某些情况下，它能减弱由输注α1-激动剂去氧肾上腺素引起的血压升高，这表明它至少部分作为一种α1-肾上腺素能受体拮抗剂起作用。然而，这种减弱作用的特异性受到了质疑。因此，我们研究了酮色林对血管紧张素II（一种基本不具有α1-激动剂特性的血管收缩剂）引起的血压和心率反应的影响。与去氧肾上腺素不同，酮色林不会减弱对输注血管紧张素II的血压反应。酮色林似乎不会增加心脏传出副交感神经活动。在用于治疗高血压的剂量下，酮色林在人体中产生α1-拮抗作用，这可能部分解释了其降压作用。
