Barrès C, Cerutti C, Devissaguet M, Paultre C, Sassard J
Département de Physiologie et Pharmacologie Clinique UA CNRS 606, Lyon, France.
J Hypertens Suppl. 1985 Dec;3(3):S207-9.
The acute cardiovascular effects of S 9490-3, a new angiotensin converting enzyme (ACE) inhibitor, were studied by means of a computerized analysis of the intra-aortic blood pressure (BP), recorded continuously for 48 h in conscious, unrestrained, adult spontaneously hypertensive rats (SHR). The first 24-h recording period was used as a control. On the second day, the rats received a single intravenous (i.v.) injection of S 9490-3 (0.2 mg/kg) at 11 a.m. followed by another 2 mg/kg i.v. injection at 3 p.m. Cardiovascular activity was studied up to 8 a.m. the next day. No significant cardiovascular effects appeared after the 0.2 mg/kg dose, whereas the 2 mg/kg dose induced a rapid fall in systolic and diastolic BP, which remained significant for about 11 h. This BP decrease was not associated with any elevation in heart rate, but with a short lasting increase in dP/dt max. These results are in good agreement with those already obtained with S 9490-3 in various experimental conditions. They suggest that long-term recordings of intra-arterial BP in freely moving rats is of value in the study of drugs which act on the cardiovascular system.
采用计算机分析清醒、无束缚成年自发性高血压大鼠（SHR）的主动脉内血压（BP），连续记录48小时，研究新型血管紧张素转换酶（ACE）抑制剂S 9490 - 3的急性心血管效应。第一个24小时记录期用作对照。第二天，大鼠于上午11点接受单次静脉注射S 9490 - 3（0.2毫克/千克），随后于下午3点再静脉注射2毫克/千克。直至第二天上午8点研究心血管活动。0.2毫克/千克剂量后未出现明显心血管效应，而2毫克/千克剂量导致收缩压和舒张压迅速下降，持续约11小时仍有显著差异。这种血压下降与心率升高无关，但与dP/dt max短暂升高有关。这些结果与在各种实验条件下用S 9490 - 3已获得的结果高度一致。它们表明，在自由活动大鼠中进行动脉内血压的长期记录对研究作用于心血管系统的药物具有价值。
