巨细胞病毒、巨噬细胞与乳腺癌
Cytomegalovirus, Macrophages and Breast Cancer.
作者信息
Pasquereau S, Al Moussawi F, Karam W, Diab Assaf M, Kumar A, Herbein G
机构信息
Pathogens & Inflammation/EPILAB Laboratory, Department of Virology, University of Franche-Comté, COMUE Bourgogne Franche-Comté University, UPRES EA4266, SFR FED 4234, CHRU Besançon, Besançon, France.
Université Libanaise, Beyrouth, Lebanon.
出版信息
Open Virol J. 2017 Mar 31;11:15-27. doi: 10.2174/1874357901711010015. eCollection 2017.
The human cytomegalovirus (HCMV) is a betaherpesvirus that is highly host specific, infects among others epithelial cells and macrophages, and has been recently mentioned as having oncomodulatory properties. HCMV is detected in the breast tumor tissue where macrophages, especially tumor associated macrophages, are associated with a poor prognosis. In this review, we will discuss the potential implication of HCMV in breast cancer with emphasis on the role played by macrophages.
人巨细胞病毒（HCMV）是一种β疱疹病毒，具有高度的宿主特异性，可感染上皮细胞和巨噬细胞等，最近被提及具有肿瘤调节特性。在乳腺肿瘤组织中可检测到HCMV，其中巨噬细胞，尤其是肿瘤相关巨噬细胞，与预后不良有关。在本综述中，我们将讨论HCMV在乳腺癌中的潜在影响，重点关注巨噬细胞所起的作用。
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