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TSCQ study: a randomized, controlled, open-label trial of daily trimethoprim-sulfamethoxazole or weekly chloroquine among adults on antiretroviral therapy in Malawi: study protocol for a randomized controlled trial.TSCQ研究：在马拉维接受抗逆转录病毒治疗的成年人中进行的每日服用甲氧苄啶-磺胺甲恶唑或每周服用氯喹的随机、对照、开放标签试验：一项随机对照试验的研究方案
Trials. 2016 Jul 18;17(1):322. doi: 10.1186/s13063-016-1392-3.
2
A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.恶性疟原虫K13螺旋桨多态性的全球地图。
N Engl J Med. 2016 Jun 23;374(25):2453-64. doi: 10.1056/NEJMoa1513137.
3
The influence of nevirapine and efavirenz-based anti-retroviral therapy on the pharmacokinetics of lumefantrine and anti-malarial dose recommendation in HIV-malaria co-treatment.基于奈韦拉平和依非韦伦的抗逆转录病毒疗法对蒿甲醚药代动力学的影响及HIV-疟疾合并治疗中抗疟剂量的推荐
Malar J. 2015 Apr 25;14:179. doi: 10.1186/s12936-015-0695-2.
4
The effect of daily co-trimoxazole prophylaxis on natural development of antibody-mediated immunity against P. falciparum malaria infection in HIV-exposed uninfected Malawian children.每日服用复方新诺明预防对马拉维暴露于HIV但未感染的儿童针对恶性疟原虫疟疾感染的抗体介导免疫自然发展的影响。
PLoS One. 2015 Mar 25;10(3):e0121643. doi: 10.1371/journal.pone.0121643. eCollection 2015.
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Duration of residency in a non-endemic area and risk of severe malaria in African immigrants.非疟疾流行区居住时间与非洲移民罹患重症疟疾的风险。
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Pharmacogenetics of CYP2B6, CYP2A6 and UGT2B7 in HIV treatment in African populations: focus on efavirenz and nevirapine.非洲人群 HIV 治疗中 CYP2B6、CYP2A6 和 UGT2B7 的药物遗传学：以依非韦伦和奈韦拉平为例。
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Increased severity and mortality in adults co-infected with malaria and HIV in Maputo, Mozambique: a prospective cross-sectional study.莫桑比克马普托疟疾与艾滋病毒合并感染成年人的病情严重程度及死亡率增加：一项前瞻性横断面研究
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两名马拉维患者在停止复方新诺明预防性治疗后不久，接受抗逆转录病毒治疗期间频繁出现疟疾发病情况。

Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy.

作者信息

Nyangulu Wongani Js, Mwinjiwa Edson, Divala Titus H, Mungwira Randy G, Nyirenda Osward, Kanjala Maxwell, Mbambo Gillian, Mallewa Jane, Taylor Terrie E, Laurens Matthew B, Laufer Miriam K, van Oosterhout Joep J

机构信息

Dignitas International, Zomba, Malawi.

Blantyre Malaria Project, College of Medicine, University of Malawi, Blantyre, Malawi.

出版信息

Malawi Med J. 2017 Mar;29(1):57-60. doi: 10.4314/mmj.v29i1.12.

DOI:10.4314/mmj.v29i1.12
PMID:28567199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5442494/
Abstract

We describe two Malawian adults on successful antiretroviral therapy who experienced frequent malaria episodes after stopping cotrimoxazole prophylaxis. We argue that, in addition to stopping cotrimoxazole, diminished malaria immunity and drug interactions between efavirenz and artemether-lumefantrine may have played a causative role in the recurrent malaria our patients experienced.

摘要

我们描述了两名接受抗逆转录病毒疗法治疗成功的马拉维成年人，他们在停止复方新诺明预防用药后频繁出现疟疾发作。我们认为，除了停止使用复方新诺明外，疟疾免疫力下降以及依非韦伦与蒿甲醚-本芴醇之间的药物相互作用可能在我们的患者所经历的复发性疟疾中起到了致病作用。