Pettersson A, Ricksten S E, Towle A, Hedner J, Hedner T
Department of Pharmacology, University of Gothenburg, Sweden.
J Hypertens Suppl. 1985 Dec;3(3):S311-3.
The atrial natriuretic peptides (ANP) are a family of newly discovered peptides which are released from atrial tissue and have potent diuretic/natriuretic, vasodilating and aldosterone inhibitory properties. Plasma concentration of ANP was measured and related to haemodynamic changes after acute blood volume expansion (10 and 20%) in normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Acute blood volume expansion resulted in an increase in central (CBV) and peripheral blood volume (PBV), central venous pressure (CVP), stroke volume (SV) and cardiac output (CO), while total peripheral resistance (TPR) and heart rate (HR) were decreased. Mean arterial pressure (MAP) was unchanged. There were larger increases in CBV, CVP and CO in SHR than in WKY rats. In contrast, the increase in PBV and the decrease in HR were more marked in the WKY rats. Basal plasma ANP concentrations were similar in both groups. Blood volume expansion caused a linear increase in plasma ANP in the WKY rats, while the increase in plasma ANP concentration was attenuated in the SHR. It is concluded that acute blood volume expansion is more centralized in the SHR than in the WKY rats. Interestingly, the ANP release in response to blood volume expansion seems to be attenuated in SHR compared with WKY rats, as maximal plasma ANP concentrations were found at 10% volume load.
心房利钠肽（ANP）是一族新发现的肽类物质，由心房组织释放，具有强大的利尿/利钠、血管舒张和抑制醛固酮的特性。测定了正常血压的Wistar-Kyoto（WKY）大鼠和自发性高血压大鼠（SHR）急性血容量扩充（10%和20%）后血浆ANP浓度及其与血流动力学变化的关系。急性血容量扩充导致中心血容量（CBV）和外周血容量（PBV）增加、中心静脉压（CVP）升高、每搏输出量（SV）和心输出量（CO）增加，而总外周阻力（TPR）和心率（HR）降低。平均动脉压（MAP）未改变。SHR的CBV、CVP和CO的增加幅度大于WKY大鼠。相反，WKY大鼠的PBV增加和HR降低更为明显。两组的基础血浆ANP浓度相似。血容量扩充使WKY大鼠的血浆ANP呈线性增加，而SHR的血浆ANP浓度增加减弱。得出的结论是，与WKY大鼠相比，急性血容量扩充在SHR中更集中于中心部位。有趣的是，与WKY大鼠相比，SHR对血容量扩充的ANP释放似乎减弱，因为在10%容量负荷时发现血浆ANP浓度最高。
