Pettersson A, Ricksten S E, Towle A C, Hedner J, Hedner T
Department of Pharmacology, Gothenburg University, Sweden.
Acta Physiol Scand. 1988 Aug;133(4):513-8. doi: 10.1111/j.1748-1716.1988.tb08435.x.
Atrial natriuretic peptide (ANP) was measured in plasma during acute volume load in conscious, spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. During basal conditions immunoreactive ANP were similar in the SHR (630 +/- 56 pmoles l-1) and the WKY (657 +/- 114 pmoles l-1) groups. An acute 10% and 20% whole blood volume expansion resulted in a linear increase in immunoreactive plasma ANP in the WKY. In the SHR the increase in plasma ANP was attenuated during the 20% volume load. During the 10% and 20% volume load central venous pressure (CVP), central blood volume (CBV) and cardiac output increased relatively more in the SHR compared with the WKY group. In contrast, the increase in peripheral blood volume (PBV) and decrease in heart rate (HR) was attenuated in the SH rats. In the SHR group there was a shift of the ANP vs. CVP and ANP vs. CBV curves to the right compared with the WKY. We conclude that acute volume loading is a potent stimulus for ANP release in WKY as well as SHR. However, in the SHR, ANP release was blunted in spite of the increased centralization of the volume load in this rat strain. Thus, the decreased responsiveness of the ANP hormonal system may contribute to the development and maintenance of hypertension in this genetic form of hypertension.
在清醒的自发性高血压大鼠（SHR）和正常血压的Wistar-Kyoto（WKY）大鼠急性容量负荷期间，检测血浆中的心房利钠肽（ANP）。在基础状态下，SHR组（630±56皮摩尔/升）和WKY组（657±114皮摩尔/升）的免疫反应性ANP相似。急性10%和20%全血容量扩充导致WKY大鼠免疫反应性血浆ANP呈线性增加。在SHR中，20%容量负荷期间血浆ANP的增加减弱。在10%和20%容量负荷期间，与WKY组相比，SHR的中心静脉压（CVP）、中心血容量（CBV）和心输出量增加相对更多。相反，SH大鼠外周血容量（PBV）的增加和心率（HR）的降低减弱。与WKY相比，SHR组中ANP与CVP以及ANP与CBV曲线向右偏移。我们得出结论，急性容量负荷是WKY和SHR中ANP释放的有效刺激因素。然而，在SHR中，尽管该大鼠品系的容量负荷集中化增加，但ANP释放仍受到抑制。因此ANP激素系统反应性降低可能有助于这种遗传性高血压形式中高血压的发生和维持。
