未曾接受过化疗的患者出现转移性囊性滋养细胞瘤的罕见病例

Rare Presentation of Metastatic Cystic Trophoblastic Tumor in a Patient Without Prior Chemotherapy.

作者信息

Wang Michael L, McHugh Jonathan B, Weizer Alon Z, Morgan Todd M, Chinnaiyan Arul M, Sciallis Andrew P, Lagstein Amir, Spratt Daniel E, Mehra Rohit

机构信息

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

Department of Urology, University of Michigan Medical School, Ann Arbor, MI, USA.

出版信息

Urol Case Rep. 2017 May 23;13:154-157. doi: 10.1016/j.eucr.2017.04.014. eCollection 2017 Jul.

DOI:10.1016/j.eucr.2017.04.014

PMID:28567335

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5443920/

Abstract

Cystic trophoblastic tumor (CTT) is a rare testicular germ cell tumor (GCT) predominantly seen in post-chemotherapy patients. It is prognostically similar to teratoma and requires no additional chemotherapy in the absence of a nonteratomatous GCT component. We report a case of metastatic CTT in a patient with primary testicular teratoma without prior chemotherapy. Retroperitoneal lymph node metastases contained teratoma, embryonal carcinoma, and CTT. The CTT was β-hCG positive and SALL4 negative by immunohistochemistry (IHC). CTT can arise in metastatic testicular GCT in treatment naïve patients. An important differential diagnosis is choriocarcinoma due to treatment implications, and SALL4 IHC may help.

摘要

囊性滋养层细胞瘤（CTT）是一种罕见的睾丸生殖细胞肿瘤（GCT），主要见于化疗后的患者。其预后与畸胎瘤相似，在不存在非畸胎瘤性GCT成分时无需额外化疗。我们报告一例原发性睾丸畸胎瘤且未接受过化疗的患者发生转移性CTT的病例。腹膜后淋巴结转移灶包含畸胎瘤、胚胎癌和CTT。免疫组化（IHC）显示CTT的β-hCG呈阳性，SALL4呈阴性。CTT可发生于未经治疗的转移性睾丸GCT患者。由于治疗影响，重要的鉴别诊断是绒毛膜癌，SALL4免疫组化可能会有所帮助。