Weidenthaler-Barth B
Hautklinik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland.
Hautarzt. 2017 Jul;68(7):536-541. doi: 10.1007/s00105-017-3995-3.
The palisading granulomatous dermatitides comprise a group of different skin diseases with similar histomorphologic forms of granuloma in the skin. Histopathologically characteristic are areas in the reticular dermis and subcutaneous fat with degenerated bundles of collagen surrounded by histiocytes and multinucleate giant cells aligned in a palisade (necrobiotic granuloma). Within the center of palisaded granulomas, mucin or fibrin can be found. The skin diseases presenting histologically with palisading granuloma are granuloma annulare and necrobiosis lipoidica. Palisading granuloma may also be an expression of systemic disease in rheumatoid nodules and necrobiotic xanthogranuloma. Little is known about the pathogenesis. The clinical presentation of the diseases is variable. Therapy is challenging and may not be satisfying.
栅栏状肉芽肿性皮炎包括一组不同的皮肤疾病，它们在皮肤中具有相似的肉芽肿组织形态学形式。组织病理学特征是网状真皮和皮下脂肪中出现区域，其中有退化的胶原束，周围有组织细胞和多核巨细胞呈栅栏状排列（坏死性肉芽肿）。在栅栏状肉芽肿的中心可发现黏液或纤维蛋白。组织学上表现为栅栏状肉芽肿的皮肤疾病有环状肉芽肿和类脂质渐进性坏死。栅栏状肉芽肿也可能是类风湿结节和坏死性黄色肉芽肿等全身性疾病的一种表现。其发病机制尚不清楚。这些疾病的临床表现各异。治疗具有挑战性，可能并不令人满意。
